临床特征对胃癌患者发生胃周软组织转移及其生存期的影响  

Effect of clinical characteristics on patients with gastric cancer developed perigastric soft tissue metastasis and its survival time

作　　者：赵宏升 潘吉勇[1] 闫瑞锋[1] 闫龙超 陈郑达 宋小海[1] 王梅 ZHAO Hongsheng;PAN Jiyong;YAN Ruifeng;YAN Longchao;CHEN Zhengda;SONG Xiaohai;WANG Mei(Department of General Surgery,Dalian Third People′s Hospital(Dalian Cancer Hospital),Liaoning Province,Dalian116033,China;Department of Pathology and Forensic Medicine,School of Basic Medicine of Dalian Medical University,Liaoning Province,Dalian116044,China)

机构地区：[1]大连市第三人民医院(大连市肿瘤医院)普外科,辽宁大连116033 [2]大连医科大学基础医学院病理学与法医学教研室,辽宁大连116044

出　　处：《中国当代医药》2022年第2期20-23,共4页China Modern Medicine

摘　　要：目的探讨临床特征对胃癌患者发生胃周软组织转移及其生存期的影响。方法回顾性分析2015年1月至2020年6月大连市第三人民医院收治的胃癌根治性切除术的412例患者的临床资料,根据是否合并胃周软组织转移分为转移组(134例)与未转移组(278例)。观察不同临床特征对胃癌患者发生胃周软组织转移的影响,以及不同临床特征对胃癌合并胃周软组织转移患者生存期的影响。结果肿瘤部位、肿瘤大小、浸润深度、淋巴结转移度、有无远处转移、Bomnann分型、分化程度、血清癌胚抗原(CEA)水平是胃癌患者发生胃周软组织转移的相关因素(P<0.05);肿瘤直径、有无脏器侵犯、淋巴结转移度、是否合并远处转移、血清CEA水平、Borrmann分型、分化程度会影响胃癌合并胃周软组织转移患者生存期(P<0.05)。结论胃癌的进展过程中胃周软组织转移常发生于肿瘤直径≥5 cm、浸润深度为T4、有远处转移、淋巴结转移度>20%、低或未分化癌、Borrmann浸润型、血清CEA>5μg/L的患者中,且发生胃周软组织转移患者的预后较差。Objective To explore the effect of clinical characteristics on patients with gastric cancer developed perigastric soft tissue metastasis and its survival time.Methods The clinical data of 412 patients with radical resection of gastric cancer admitted to Dalian Third People′s Hospital from January 2015 to June 2020 were retroreviewed,and divided into the metastasis group(134 cases)and the untransferred group(278 cases)according to whether perigastric soft tissue metastasis was combined.The effect of different clinical characteristics on the development of perigastric soft tissue metastasis in gastric cancer patients,and the impact of different clinical characteristics on the survival of patients with gastric cancer and perigastric soft tissue metastasis were observed.Results The tumor site,tumor size,depth of infiltration,lymph node metastasis,presence of distant metastasis,Bomnann typing,differentiation,serum carcinoem bryonic antigen(CEA)level were related with gastric soft tissue metastasis(P<0.05).The tumor diameter,organ invasion,lymph node metastasis,combination of distant metastasis,serum CEA level,Borrmann classification and differentiation affected the survival of patients with gastric cancer and gastric soft tissue metastasis(P<0.05).Conclusion Soft tissue metastasis of gastric cancer often occurs in patients with≥5 cm tumor diameter,infiltration depth of T4,with distant metastasis,lymph node metastasis degree>20%,low or undifferentiated carcinoma,Borrmann infiltration type,serum CEA>5 g/L,and poor prognosis in patients with perigastric soft tissue metastasis.

关 键 词：胃肿瘤 肿瘤转移 临床病理学 预后 

分 类 号：R642[医药卫生—外科学]