阿奇霉素联合丙酸氟替卡松治疗肺炎支原体感染所致小儿慢性咳嗽的临床效果  

Clinical effect of Azithromycin combined with Fluticasone Propionate on pediatric chronic cough caused by Mycoplasma pneumoniae infection

作　　者：吴小玲[1] 黄翠兰[1] 王珍春 WU Xiaoling;HUANG Cuilan;WANG Zhenchun(Department of Neonatology,the First Affiliated Hospital of Guangxi University of Science and Technology,Guangxi Province,Liuzhou545000,China)

机构地区：[1]广西科技大学第一附属医院新生儿科,广西柳州545000

出　　处：《中国当代医药》2022年第2期116-118,共3页China Modern Medicine

摘　　要：目的探讨阿奇霉素联合丙酸氟替卡松对肺炎支原体(MP)感染所致慢性咳嗽患儿的效果。方法选取2018年9月至2019年8月广西科技大学第一附属医院新生儿科收治的126例MP感染的慢性咳嗽患儿作为研究对象,采用随机数字表法将其分为观察组和对照组,各63例。对照组给予阿奇霉素治疗,观察组在此基础上给予丙酸氟替卡松治疗。比较两组临床疗效、呼出气一氧化氮(FeNO)、C反应蛋白(CRP)、嗜酸性粒细胞(EOS)计数、咳嗽复发率。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后的血清CRP、EOS计数、FeNO均低于对照组,差异有统计学意义(P<0.05)。观察组咳嗽复发率低于对照组,差异有统计学意义(P<0.05)。结论对MP感染慢性咳嗽患儿实施阿奇霉素联合丙酸氟替卡松治疗,能进一步提高治疗效果,且可减少病情复发。Objective To investigate the effect of Azithromycin combined with Fluticasone Propionate on pediatric chronic cough caused by Mycoplasma pneumoniae(MP)infection.Methods A total of 126 children with MP infection and chronic cough admitted to the Department of Neonatology,the First Affiliated Hospital of Guangxi University of Science and Technology from September 2018 to August 2019 were selected as the research objects,and they were divided into observation group and control group by random number table method,63 cases in each group.The control group was treated by Azithromycin,and the observation group was given the same but combined with Fluticasone Propionate.The clinical efficacy,fractional exhaled nitric oxide(FeNO),C-reactive protein(CRP),eosinophil(EOS)counts,and cough relapse rates of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The serum CRP,EOS and FeNO in the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The recurrence rate of cough in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of Azithromycin combined with Fluticasone Propionate in children with chronic cough with MP infection can further improve the treatment effect and reduce the recurrence.

关 键 词：阿奇霉素 丙酸氟替卡松 肺炎支原体感染 慢性咳嗽患儿 效果 

分 类 号：R725[医药卫生—儿科]