阿司匹林肠溶缓释片抗栓作用的研究进展  

Research progress in antithrombotic effect of aspirin enteric-coated sustained release tablet

作　　者：陈强 韩冰 Chen Qiang;Han Bing(Chengde Medical College,Chengde 067000,Hebei,China;Department of Vascular Surgery,Baoding Second Central Hospital,Baoding 072750,Hebei,China)

机构地区：[1]承德医学院,河北承德067000 [2]保定市第二中心医院血管外科,河北保定072750

出　　处：《血管与腔内血管外科杂志》2021年第10期1207-1209,共3页Journal of Vascular and Endovascular Surgery

摘　　要：阿司匹林是临床上常用的经典抗血小板药物,虽然其抗血小板聚集的作用十分明显,但经常会导致胃肠道不良反应和出血事件的发生。阿司匹林肠溶缓释片在发挥抗血小板聚集作用的同时,以其在肠道内缓慢释放药物的特点,使体内血药浓度更加趋于稳定,可以更好地发挥其抗血栓作用,同时也可以减少不良反应的发生。本文对阿司匹林肠溶缓释片的作用机制、抗血栓作用及药物联合使用情况进行综述。Aspirin is a classic antiplatelet drug commonly used in clinic.Although the antiplatelet aggregation effect is significant,the drug frequently causes gastrointestinal adverse reactions and bleeding events.Aspirin entericcoated sustained release tablets not only play an anti-platelet aggregation role,but also have the characteristics of slow release of drugs in the intestine,so that the blood drug concentration in the body is more stable,which can better take antithrombotic effect and reduce the occurrence of adverse reactions.This paper reviews the mechanism of aspirin enteric-coated sustained release tablets,the advantages of antithrombotic effect and the combined use of drugs.

关 键 词：血小板聚集 阿司匹林肠溶缓释片 抗栓作用 

分 类 号：R543[医药卫生—心血管疾病]