中医药干预基质金属蛋白酶表达治疗膝骨性关节炎研究进展  

Research progress in the treatment of knee osteoarthritis by intervention of matrix metalloproteinase expression with traditional Chinese medicine

作　　者：李辉 李宁[1] 谢兴文 李建国 李鼎鹏 柳博 丁聚贤 LI Hui;LI Ning;XIE Xingwen;LI Jianguo;LI Dingpeng;LIU Bo;DING Juxian(Gansu University of Traditional Chinese Medicine,Lanzhou 730000;The Second People’s Hospital of Gansu Province,Lanzhou 730030;The Affiliated Hospital of Northwest University for Nationalities,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省第二人民医院,甘肃兰州730030 [3]西北民族大学附属医院,甘肃兰州730030

出　　处：《中国骨质疏松杂志》2022年第1期120-123,138,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(62060873);中央引导地方科技发展专项(甘科资函[2020]60号);甘肃省中医药管理局科研课题(GZK-2019-25);敦煌医学与转化教育部重点实验室开放课题(DHYX19-05);甘肃省中医药研究中心开放课题(zyzx-2020-32);中央高校基本科研业务服务费项目(31920210041)。

摘　　要：膝骨性关节炎是临床上常见的慢性进行性关节病,症状通常以疼痛及关节功能丧失为主。其病因复杂,发病机制尚未完全阐明,对该病的有效防治一直是临床研究的热点。近年来,随着对基质金属蛋白酶与骨性关节炎关系研究的不断深入,发现基质金属蛋白酶通过影响关节软骨破坏这一重要病理过程,在其发生和发展过程中扮演重要角色。大量研究资料表明,中医药可干预膝骨性关节炎患者基质金属蛋白酶表达,抑制软骨细胞外基质降解,从而减轻膝骨性关节炎的临床症状及延缓病理进程。笔者就中医药干预基质金属蛋白酶表达治疗膝骨性关节炎的研究进展进行综述,以期为中医药应用于膝骨性关节炎的防治提供参考和依据。Knee osteoarthritis(OA)is a common chronic progressive joint disease with pain and loss of joint function.The etiology of this disease is complex and its pathogenesis has not been fully elucidated.In recent years,with the deepening of research on the relationship between matrix metalloproteinases and OA,it has been found that matrix metalloproteinases play an important role in the occurrence and development of OA by affecting the important pathological process of articular cartilage destruction.A large number of studies have shown that traditional Chinese medicine(TCM)interferes with the expression of matrix metalloproteinases in patients with knee OA and inhibits the degradation of extracellular chondrocyte matrix,thus reducing the clinical symptoms and delaying the pathological process of knee OA.This paper reviews the research progress of TCM intervention on matrix metalloproteinase expression in the treatment of knee OA,in order to provide reference and basis for the application of TCM in the prevention and treatment of knee OA.

关 键 词：膝骨性关节炎 基质金属蛋白酶 中医药 

分 类 号：R684.3[医药卫生—骨科学] R285[医药卫生—外科学]