破骨细胞能量代谢的研究进展  

The research progresses in energy metabolism of osteoclasts

作　　者：王银博 孙维佳[2] 李玉恒[2] 凌树宽[2] 李英贤 WANG Yinbo;SUN Weijia;LI Yuheng;LING Shukuan;LI Yingxian(Department of Aerospace Medicine,Air Force Medical University,Xi’an 710038;State Key Laboratory of Space Medicine Fundamentals and Application,China Astronaut Research and Training Center,Beijing 100094,China)

机构地区：[1]空军军医大学航天航空医学系,陕西西安710038 [2]中国航天员科研训练中心航天医学基础与应用国家重点实验室,北京100094

出　　处：《中国骨质疏松杂志》2022年第1期139-142,共4页Chinese Journal of Osteoporosis

摘　　要：破骨细胞在骨代谢中发挥重要的噬骨功能,其分化成熟和功能发挥对骨代谢具有重要意义。破骨细胞分化和发挥功能阶段都需要能量代谢的参与,能量代谢的异常会导致破骨细胞分化功能的异常,从而导致骨代谢的异常。本文拟从能量代谢的角度综述破骨细胞分化和发挥功能的不同阶段,其主要的能量来源和调控机制。Osteoclasts play an important role in bone erosion function in bone metabolism,and their differentiation and function are of great significance in bone metabolism.Both osteoclast differentiation and function stages require the participation of energy metabolism.Abnormal energy metabolism may lead to abnormal differentiation of osteoclasts,which leads to abnormal bone metabolism.This article intends to review the different stages of osteoclast differentiation and function from the perspective of energy metabolism,its main energy sources,and regulatory mechanism.

关 键 词：破骨细胞 能量代谢 调控机制 

分 类 号：R336[医药卫生—人体生理学] R682[医药卫生—基础医学]