脓毒症患者抗菌药物药物代谢动力学和药物效应动力学研究进展  

Research progress on pharmacokinetics and pharmacodynamics of antibiotics in sepsis

作　　者：毛文超 李莉[2] 严静[2] Mao Wenchao;Li Li;Yan Jing(The Second Clinical Medical College,Zhejiang Chinese Medicine University,Hangzhou 310053,Zhejiang,China;Department of Critical Care Medicien,Zhejiang Hospital,Hangzhou 310013,Zhejiang,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江医院重症医学科,浙江杭州310013

出　　处：《中国中西医结合急救杂志》2021年第5期634-637,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：国家自然科学基金(81772051)。

摘　　要：脓毒症是机体对感染反应失调而引起的器官功能障碍,病死率很高,合理使用抗菌药物是降低脓毒症患者病死率的关键。但是临床抗感染治疗经常失败,原因之一是脓毒症患者对抗菌药物的药物代谢动力学(PK)和药物效应动力学(PD)发生了变化。因此,掌握PK和PD知识有助于正确应用抗菌药物,降低脓毒症患者的病死率。现拟对脓毒症患者PK变化以及通过PK和PD优化抗菌药物给药方案的相关研究进展进行综述。Sepsis is a sequence of sequential organ dysfunction caused by imbalance of organism response to infection,and the mortality is very high.Rational use of antibiotics is the key to reduce the mortality of patients with sepsis.However,using antibiotics for treatment of sepsis clinically often obtains failure result.One of the causes is the occurrence of pharmacokinetic(PK)and pharmacodynamic(PD)changes of antibiotics in the septic patient,inducing the failure.Therefore,mastering PK/PD knowledge is conducive to the correct application of antibiotics and the reduction of mortality in septic patients.Here,the authors intend to review the progress of researches related to changes of PK in septic patients and via PK and PD to optimize antibiotic dosing regimens in sepsis.

关 键 词：脓毒症 抗菌药物 药物代谢动力学 药物效应动力学 

分 类 号：R47[医药卫生—护理学]