独活寄生汤辅助臭氧髓核消融术治疗盘源性腰痛临床研究  

Clinical Effect of Duhuo Jisheng Tang Assisting Ozone Nucleus Pulposus Ablation for Discogenic Low Back Pain

作　　者：张魁贤 吴惠明[1] 张帆[1] 张里援[1] 刘海峰[1] ZHANG Kuixian;WU Huiming;ZHANG Fan;ZHANG Liyuan;LIU Haifeng

机构地区：[1]浙江中医药大学附属温州市中医院骨伤科,浙江温州325000

出　　处：《新中医》2021年第23期39-42,共4页New Chinese Medicine

摘　　要：目的:观察独活寄生汤辅助臭氧髓核消融术治疗盘源性腰痛(DLBP)的临床疗效。方法:选取90例DLBP患者,按随机数字表法分为对照组和观察组各45例。对照组采用臭氧髓核消融术治疗,观察组在对照组基础上给予独活寄生汤口服。比较2组临床疗效,检测治疗前后疼痛视觉模拟评分法(VAS)评分、日本骨科协会(JOA)评分、血清炎症因子白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的表达。结果:观察组总有效率为95.56%,高于对照组82.22%,差异有统计学意义(P<0.05)。治疗前,2组VAS评分比较,差异无统计学意义(P>0.05)。治疗后1个月、3个月、6个月,2组VAS评分逐渐降低(P<0.05),且观察组治疗后1个月、3个月、6个月VAS评分均低于对照组(P<0.05)。治疗前,2组JOA评分比较,差异无统计学意义(P>0.05)。治疗后1个月、3个月、6个月,2组JOA评分逐渐升高(P<0.05),且观察组治疗后1个月、3个月、6个月JOA评分均高于对照组(P<0.05)。治疗前,2组IL-1、IL-6、TNF-α水平比较,差异无统计学意义(P>0.05)。治疗后,2组IL-1、IL-6、TNF-α水平低于治疗前,且观察组IL-1、IL-6、TNF-α水平低于对照组,差异均有统计学意义(P<0.05)。结论:独活寄生汤辅助臭氧髓核消融术对DLBP患者的疗效较好,可以降低疼痛程度,改善脊柱功能,降低血清炎症因子的表达。Objective:To observe the clinical effect of Duhuo Jisheng tang assisting ozone nucleus pulposus ablation for discogenic low back pain(DLBP).Methods:A total of 90 cases of DLBP patients were selected and divided into the control group and the observation group according to random number table method,with 45 cases in each group.The control group was given ozone nucleus pulposus ablation,and the observation group was additionally treated with the oral administration of Duhuo Jisheng tang based on the treatment of the control group.The clinical effects were compared between the two groups.Before and after treatment,scores of Visual Analogue Scale(VAS)for pain evaluation and Japanese Orthopaedic Association(JOA),as well as the expression of inflammatory factors including interleukin-1(IL-1),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in serum were detected.Results:The total effective rate was 95.56%in the observation group,higher than that of 82.22%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of VAS scores between the two groups(P>0.05).In one month,three months and six months after treatment,VAS scores in the two groups were gradually decreased(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of JOA scores between the two groups(P>0.05).In one month,three months and six months after treatment,JOA scores in the two groups were gradually increased(P<0.05),and the scores in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of IL-1,IL-6 and TNF-αbetween the two groups(P>0.05).After treatment,levels of IL-1,IL-6 and TNF-αin the two groups were lower than those before treatment,and the three levels in the observation group were lower than those in the control group,d

关 键 词：盘源性腰痛 独活寄生汤 臭氧髓核消融术 视觉模拟评分法 功能障碍 炎症因子 

分 类 号：R681[医药卫生—骨科学]