安宫牛黄丸辅助常规基础疗法治疗急性重症颅脑外伤昏迷临床研究  

Clinical Study on Angong Niuhuang Pills Assisting Routine Basic Therapy for Coma Due to Acute Severe Traumatic Brain Injury

作　　者：姚建亮 毛平安[1] 袁垒 黄平香[1] YAO Jianliang;MAO Pingan;YUAN Lei;HUANG Pingxiang

机构地区：[1]丽水市人民医院康复科,浙江丽水323000 [2]新余市人民医院康复医学科,江西新余338004

出　　处：《新中医》2021年第23期47-51,共5页New Chinese Medicine

摘　　要：目的:观察安宫牛黄丸辅助常规基础疗法治疗急性重症颅脑外伤昏迷患者的促醒作用及对血清B型利钠肽(BNP)、超敏C-反应蛋白(hs-CRP)水平的影响。方法:将50例急性重症颅脑外伤昏迷患者按随机数字表法分为对照组和观察组各25例。对照组给予常规基础治疗,观察组在对照组基础上给予安宫牛黄丸治疗。比较2组治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、格拉斯哥昏迷量表(GCS)评分、血清BNP、hs-CRP水平变化,并评价2组临床疗效、促醒效果和并发症发生情况。结果:观察组总有效率为88.00%,高于对照组的64.00%,差异有统计学意义(P<0.05)。观察组苏醒率(84.00%)高于对照组(56.00%),且苏醒时间早于对照组(P<0.05)。2组治疗后NIHSS评分低于治疗前,GCS评分高于治疗前(P<0.05);观察组治疗后NIHSS评分低于对照组,GCS评分高于对照组(P<0.05)。2组治疗后血清BNP水平高于治疗前,hs-CRP水平低于治疗前(P<0.05);观察组治疗后BNP水平高于对照组,hs-CRP水平低于对照组(P<0.05)。观察组并发症发生率为12.00%,低于对照组的40.00%,差异有统计学意义(P<0.05)。结论:安宫牛黄丸辅助常规基础疗法治疗急性重症颅脑外伤昏迷患者疗效显著,可缩短患者苏醒时间,改善神经功能缺损程度及昏迷程度,减轻机体炎症反应,减少并发症,有利于改善患者预后。Objective:To observe the wake-promoting effect of Angong Niuhuang pills assisting routine basic therapy for patients with coma due to acute severe traumatic brain injury and its effect on the levels of B-type natriuretic peptide(BNP)and high-sensitivity C-reactive protein(hs-CRP)in serum.Methods:A total of 50 cases of patients with coma due to acute severe traumatic brain injury were divided into the control group and the observation group according to the random number table method,with 25 cases in each group.The control group was given routine basic treatment,and the observation group was additionally treated with Angong Niuhuang pills based on the treatment of the control group.The changes in the scores of National Institutes of Health Stroke Scale(NIHSS)and Glasgow Coma Scale(GCS)as well as the levels of BNP and hs-CRP in serum before and after treatment in the two groups were compared;clinical effects,wake-promoting effects and the incidences of complications in the two groups were evaluated.Results:The total effective rate was 88.00%in the observation group,higher than that of 64.00%in the control group,the difference being significant(P<0.05).The awaking rate was 84.00%in the observation group,higher than that of 56.00%in the control group,and the recovery time in the observation group was earlier than that in the control group(P<0.05).After treatment,NIHSS scores in the two groups were lower than those before treatment,and GCS scores were higher(P<0.05);NIHSS score in the observation group was lower than that in the control group,and GCS score was higher(P<0.05).After treatment,serum BNP levels in the two groups were higher than those before treatment,and hs-CRP levels were lower(P<0.05);BNP level in the observation group was higher than that in the control group,and hs-CRP level was lower(P<0.05).The incidence of complications was 12.00%in the observation group,lower than that of 40.00%in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Angong Niuhuang pills assisting

关 键 词：急性重症颅脑外伤 昏迷 安宫牛黄丸 B型利钠肽 超敏C-反应蛋白 美国国立卫生研究院卒中量表 格拉斯哥昏迷量表 

分 类 号：R651.15[医药卫生—外科学] R285.6[医药卫生—临床医学]