血清OPG、TNF-α、IL-6水平与糖尿病肾病的关系  

The relationship between serum OPG,TNF-α,IL-6 levels and diabetic nephropathy

作　　者：张翠平 ZHANG Cuiping(Department of Clinical Laboratory,Huai'an Chinese Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Huai'an,Jiangsu 223001,China)

机构地区：[1]南京中医药大学附属淮安市中医院检验科,江苏淮安223001

出　　处：《检验医学与临床》2022年第2期189-192,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清骨保护素(OPG)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)水平与糖尿病肾病(DN)的关系。方法选择2016年11月至2018年11月在该院内分泌科住院的2型糖尿病患者123例为研究对象,根据尿微量清蛋白(mALB)水平将患者分为糖尿病无肾病组(DM组,mALB<20μg/min)42例,早期DN组(20μg/min≤mALB<200μg/min)40例,临床DN组(mALB≥200μg/min)41例,另选取30例健康体检者作为对照(NC组)。采用双抗体夹心法检测各组研究对象血清OPG、TNF-α、IL-6水平并进行比较,分析血清OPG、TNF-α、IL-6水平间的相关性及其对DN发生的影响。结果早期DN组、临床DN组血清OPG、IL-6水平高于NC组和DM组,临床DN组血清OPG、IL-6水平均高于早期DN组,差异有统计学意义(P<0.05);临床DN组血清TNF-α水平高于NC组和DM组,差异有统计学意义(P<0.05)。相关性分析结果显示,血清OPG水平与IL-6水平呈正相关(r=0.597,P=0.02);血清TNF-α水平与IL-6水平呈正相关(r=0.628,P=0.01)。Logistic回归分析结果显示,血清IL-6、OPG、TNF-α水平升高是引起DN发生的危险因素(P<0.05)。结论血清OPG、TNF-α、IL-6水平升高与DN的发生、发展有关,是DN发生的危险因素。Objective To explore the relationship between serum osteoprotegerin(OPG),tumor necrosis factor α(TNF-α),interleukin 6(IL-6) levels and diabetic nephropathy(DN).Methods A total of 123 patients with type 2 diabetes who were hospitalized in the endocrinology department of the hospital from November 2016 to November 2018 were selected as the research objects.According to the level of urinary microalbumin(mALB),patients were divided into diabetic without nephropathy group(DM group, mALB<20 μg/min) 42 cases, early DN group(20 μg/min≤mALB<200 μg/min) 40 cases, and clinical DN group(mALB≥200 μg/min) 41 cases.Another 30 healthy subjects were selected as the control(NC group).The double antibody sandwich method was used to detect the serum OPG,TNF-α and IL-6 levels in each group of subjects and compared.Analyzed the correlation between serum OPG,TNF-α,IL-6 levels and their influence on the occurrence of DN.Results The levels of serum OPG and IL-6 in early DN group and clinical DN group were higher than those in NC group and DM group, and the serum OPG and IL-6 levels in clinical DN group were higher than those in early DN group, the differences were statistically significant(P<0.05).The level of serum TNF-α in clinical DN group was higher than that in NC group and DM group, the differences were statistically significant(P<0.05).The results of correlation analysis showed that serum OPG level correlated positively with IL-6 level(r=0.597,P=0.02);serum TNF-α level correlated positively with IL-6 level(r=0.628,P=0.01).Logistic regression analysis showed that serum IL-6,OPG and TNF-α levels increased were the risk factors for the occurrence of DN(P<0.05).Conclusion The elevated serum OPG,TNF-α,IL-6 levels relate to the occurrence and development of DN,and are risk factors for the occurrence of DN.

关 键 词：糖尿病肾病 骨保护素 肿瘤坏死因子Α 白细胞介素6 

分 类 号：R587.2[医药卫生—内分泌]