复合固体碱催化一锅法合成愈创木酚甘油醚研究  

Study on the One-Step Synthesis of Guaiacol Glycerol Ether Catalyzed by Composite Solid Base

作　　者：陈昌略 王必伟 CHEN Changlue;WANG Biwei(Zhejiang Hai Zhou Pharmaceutical Co.Ltd.,Linhai,Zhejiang 317000)

机构地区：[1]浙江海洲制药有限公司,浙江临海317000

出　　处：《化工生产与技术》2021年第6期9-11,I0003,共4页Chemical Production and Technology

摘　　要：以邻苯二酚与α-氯代丙烯和溴甲烷为原料,在复合固体碱催化剂作用下,研究了固体碱催化一锅法合成愈创木酚甘油醚的方法,讨论了原料配比、溶剂、温度、时间和催化剂对反应的影响。结果表明,在室温加入次氯酸钠水溶液后,逐渐升温到60℃搅拌反应3 h后,收率91.8%。产物经核磁共振、红外光谱和质谱确认。With catechol,α-chloropropene and bromomethane as raw materials,the one-step synthesis of guaiacol glycerol ether catalyzed by composite solid base was studied.The effects of raw material ratio,solvent,temperature,time and catalyst on the reaction were discussed.The results showed that the yield was 91.8%after adding sodium hypochlorite aqueous solution at room temperature,then gradually heating to 60℃and keep reaction temperature of 60℃for 3 h.The product was confirmed by NMR,IR and MS.

关 键 词：愈创木酚甘油醚 固体碱 催化 一锅法 合成 

分 类 号：TQ243.24[化学工程—有机化工]