南昌市2016—2019年HBsAg阳性母亲所生婴儿乙肝疫苗接种与母婴阻断效果分析  

Hepatitis B vaccination and it’s blocking effect to hepatitis B virus among infants born to HBsAg positive mothers in Nanchang City from 2016 to 2019

作　　者：谭楚生[1] 陈福辉[1] 赵玉芹[1] 伍凤云[1] 张洪荣[1] 郭世成[1] 程慧健[1] 刘从龙 TAN Chu-sheng;CHEN Fu-hui;ZHAO Yu-qin;WU Feng-yun;ZHANG Hong-rong;GUO Shi-cheng;CHENG Hui-jian;LIU Cong-long(Jiangxi Provincial Center for Disease Control and Prevention,Nanchang 330000,Jiangxi China)

机构地区：[1]江西省疾病预防控制中心,江西南昌330000

出　　处：《安徽预防医学杂志》2021年第6期466-469,共4页Anhui Journal of Preventive Medicine

摘　　要：目的了解南昌市两个县区乙肝疫苗(HepB)和乙肝免疫球蛋白(HBIG)阻断乙肝母婴传播效果。方法对两个县区2016—2019年乙型肝炎表面抗原(HBsAg)阳性母亲所生婴儿实施HepB和HBIG联合免疫,检测血清HBsAg水平,分析HepB和HBIG接种率和免疫后婴儿HBsAg阳性率。结果HBsAg阳性母亲分娩的2609名新生儿首针HepB接种率为99.9%,首针HepB及时接种率为99.4%,HBIG接种率和及时接种率分别为100%和98.9%,3剂次HepB全程接种率和全程及时接种率分别为98.6%和30.7%。婴儿HBsAg阳性率为0.54%(14/2609)。乙肝病毒e抗原(HBeAg)和HBsAg双阳性母亲与仅HBsAg阳性母亲所生婴儿的HBsAg阳性率分别为2.00%和0.10%(χ_(校正)^(2)=27.874,P<0.001)。结论HepB和HBIG联合免疫对阻断HBV母婴传播有重要作用。HBsAg和HBeAg双阳性孕妇进行抗病毒治疗,同时应尽量规范接种HepB疫苗。Objective To study the blocking effect of hepatitis B vaccine(HepB)and Hepatitis B immunoglobulin(HBIG)on mother-to-child transmission of hepatitis B virus(HBV)in two counties of Nanchang City.Methods Infants born to hepatitis B surface antigen(HBsAg)positive mothers in two counties from 2016 to 2019 were immunized with HepB and HBIG.The level of serum HBsAg was detected,and the vaccination rate of HepB and HBIG and the HBsAg positive rate of infants after immunization were statistically analyzed.Results Among 2609 newborns delivered by HBsAg positive mothers,the first dose HepB vaccination rate was 99.9%,the first dose HepB timely vaccination rate was 99.4%,the HBIG vaccination rate and timely vaccination rate were 100%and 98.9%respectively,and the whole dose HepB vaccination rate and whole dose timely vaccination rate were 98.6%and 30.7%respectively.The positive rate of HBsAg in infants was 0.54%(14/2609).The HBsAg positive rate of infants born to hepatitis B virus e antigen(HBeAg)and HBsAg double positive mothers,and HBsAg positive mothers were 2.00%and 0.10%respectively(χ^(2)corrected=27.874,P<0.001).Conclusion Combined immunization with HepB and HBIG plays an important role in blocking mother to child transmission of HBV.Pregnant women with double positive HBsAg and HBeAg should receive antiviral treatment,and HepB vaccine should be vaccinated as standardized as possible.

关 键 词：乙肝疫苗 乙肝免疫球蛋白 乙肝表面抗原 母婴传播 

分 类 号：R173[医药卫生—妇幼卫生保健]