和血明目片联合卵磷脂络合碘治疗视网膜静脉阻塞的临床研究  

Clinical study on Hexue Mingmu Tablets combined with iodized lecithin in treatment of retinal vein occlusion

作　　者：王圆月[1] 刘军[1] 张向立[2] WANG Yuan-yue;LIU Jun;ZHANG Xiang-li(Department of Ophthalmology,Luohe Central Hospital,Luohe 462300,China;Department of Ophthalmology,the 7 th People’s Hospital of Zhengzhou,Zhengzhou 450016,China)

机构地区：[1]漯河市中心医院眼科,河南漯河462300 [2]郑州市第七人民医院眼科,河南郑州450016

出　　处：《现代药物与临床》2021年第12期2587-2591,共5页Drugs & Clinic

基　　金：河南省医学科技攻关计划项目(2018020854)。

摘　　要：目的探讨和血明目片联合卵磷脂络合碘胶囊治疗视网膜静脉阻塞的临床疗效。方法选取2017年8月—2020年11月在漯河市中心医院就诊的80例视网膜静脉阻塞患者作为研究对象,共80眼,按照随机数字表法将所有患者分为对照组和治疗组,每组各40例、40眼。对照组口服卵磷脂络合碘胶囊,0.3 mg/次,3次/d。治疗组在对照组治疗基础上口服和血明目片,1.5 g/次,3次/d。两组患者连续治疗2个月。观察两组治疗后的治疗效果,比较两组的眼压、最佳矫正视力、患眼动脉的血流动力学水平以及血清中肿瘤坏死因子-α(TNF-α)、脂联素(ADPN)、白细胞介素-8(IL-8)水平。结果治疗后,治疗组的总有效率(85.00%)比对照组的总有效率(65.00%)高(P<0.05)。治疗后,两组的眼压明显降低,最佳矫正视力明显升高(P<0.05);且治疗组的眼压比对照组低,最佳矫正视力比对照组高(P<0.05)。治疗后,两组的收缩期最大流速(PSV)、舒张末期血流速度(EDV)显著升高,血管阻力指数(RI)显著降低(P<0.05);且治疗组的PSV、EDV比对照组高,RI比对照组低(P<0.05)。治疗后,两组的血清TNF-α、ADPN、IL-8水平明显降低(P<0.05);且以治疗组血清TNF-α、ADPN、IL-8水平降低更明显(P<0.05)。结论和血明目片联合卵磷脂络合碘胶囊治疗视网膜静脉阻塞的疗效确切,能够改善患眼的血流动力学水平、最佳矫正视力和眼压,有助于减轻炎症反应,治疗安全性较高。Objective To investigate the clinical effect of Hexue Mingmu Tablets combined with Iodized Lecithin Capsules in treatment of retinal vein occlusion. Methods Patients(80 cases or 80 eyes) with retinal vein occlusion in Luohe Central Hospital from August 2017 to November 2020 were randomly divided into control and treatment groups, and each group had 40 cases or 40 eyes. Patients in the control group were po administered with Iodized Lecithin Capsules, 0.3 mg/time, three times daily. Patients in the treatment group were po administered with Hexue Mingmu Tablets on the basis of the control group, 1.5 g/time, three times daily. Patients in two groups were treated for 2 months. After treatment, the clinical efficacies were evaluated, and intraocular pressure, best corrected visual acuity, hemodynamics indexes, and TNF-α, ADPN, and IL-8 in two groups were compared. Results After treatment, the total effective rate of the treatment group(85.00%) was higher than that of the control group(65.00%)(P < 0.05). After treatment, the intraocular pressure in two groups were significantly decreased, but the best corrected visual acuity in two groups were significantly increased(P < 0.05). After treatment, the intraocular pressure in the treatment group was lower than that in the control group, but the best corrected visual acuity in the treatment group was higher than that in the control group(P < 0.05). After treatment, the PSV and EDV in two groups were significantly increased, but the RI in two groups were significantly decreased(P < 0.05). After treatment, the PSV and EDV in the treatment group were higher than those in the control group, but RI in the treatment group was lower than that in the control group(P < 0.05). After treatment, the serum levels of TNF-α, ADPN, and IL-8 in two groups were significantly decreased(P < 0.05). After treatment, the serum levels of TNF-α, ADPN, and IL-8 in the treatment group were significantly lower than those in the control group(P < 0.05). Conclusion Hexue Mingmu Tablets combined with

关 键 词：和血明目片 卵磷脂络合碘胶囊 视网膜静脉阻塞 眼压 最佳矫正视力 血流动力学 炎症反应 

分 类 号：R988.1[医药卫生—药品]