间充质干细胞在急性肾损伤中免疫调节作用的研究进展  

Research advances in immunomodulatory effect of mesenchymal stem cells in acute kidney injury

作　　者：郑志民[1] 杨红霞[1] 申众辉[1] 陈健文[2] ZHENG Zhimin;YANG Hongxia;SHEN Zhonghui;CHEN Jianwen(Department of Pharmacology,School of Medicine,Yongzhou Vocational and Technical College,Yongzhou 425000,Hunan Province,China;Department of Nephrology,the First Medical Center,Chinese PLA General Hospital,Chinese PLA Institute of Nephrology,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Diseases,Beijing 100853,China)

机构地区：[1]永州职业技术学院医学院药理学教研室,湖南永州425000 [2]解放军总医院第一医学中心肾脏病科,解放军肾脏病研究所,肾脏疾病国家重点实验室,国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室,北京100853

出　　处：《解放军医学院学报》2021年第11期1207-1210,1229,共5页Academic Journal of Chinese PLA Medical School

基　　金：湖南省教育厅科学研究项目(19C1855);国家自然科学基金项目(82100713);中国博士后科学基金(2021T140791)。

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)为干细胞家族重要成员之一,可从骨髓、脂肪、脐带、外周血等多种组织中分离获得,具有强大的免疫调节作用,可广泛调节先天和适应性免疫系统。在急性肾损伤(acute kidney injury,AKI)中,MSCs可通过调节免疫、抑制全身及局灶炎症反应,减轻肾损伤、促进组织再生。本文回顾MSCs在AKI中发挥的免疫调节作用机制及其近年来的研究进展,旨在为AKI的临床治疗提供新的思路和方向。Mesenchymal stem cells(MSCs), one of the important members of the stem cell family, can be isolated from bone marrow, adipose tissue, umbilical cord, peripheral blood and other tissues. They play a strong immune regulatory role and can widely regulate the innate and adaptive immune system. In acute kidney injury(AKI), MSCs can alleviate kidney injury and promote tissue regeneration by regulating the immune system and inhibiting systemic and focal inflammatory responses. In this paper, we review the mechanism and research advances in MSCs in the immunoregulatory role of AKI in recent years, aiming to provide new ideas and directions for the clinical treatment of acute kidney injury.

关 键 词：间充质干细胞 急性肾损伤 免疫调节 炎症反应 修复 

分 类 号：R692.6[医药卫生—泌尿科学]