Meso-四(4-O-取代苯基)卟啉化合物的合成研究  

Study on the Synthesis of Meso-tetrakis(4-O-substituted phenyl)Porphyrins

作　　者：潘继刚[1] 王斌 李敏[1] 黄月君 Pan Jigang;Wang Bin;Li Min;Huang Yuejun(School of Chemistry and Chemical Engineering,Shanxi University,Shanxi,030006;Shanxi Pharmaceutical Vocational College,Shanxi,030031)

机构地区：[1]山西大学化学化工学院,山西030006 [2]山西药科职业学院,山西030031

出　　处：《当代化工研究》2021年第24期168-170,共3页Modern Chemical Research

摘　　要：本工作以4-O-取代苯甲醛与吡咯为反应物,在苯甲醚-硝基苯溶剂中,用二氯乙酸、间硝基苯甲酸进行催化合成了Meso-四(4-O-取代苯基)卟啉化合物;然后利用索氏提取器,通过二氯甲烷-乙醇混合溶剂进行提取,制备了高纯度的卟啉化合物。该制备方法具有合成简单、产率理想及纯度高的优点。A number of meso-tetrakis(4-O-substituted phenyl)porphyrins were synthesized by condensing pyrrole with 4-hydroxybenzaldehyde and other 4-O-substituted benzaldehydes using anisole-nitrobenzene as the solvent in the presence of dichloroacetic acid or 3-nitrobenzoic acid as the catalyst.High purity porphyrin products were obtained by Soxhlet extraction of the crude product with dichloromethane-ethanol as mixed solvents.Advantages of the new method include operational simplicity of the synthetic and purification processes,good yield and high purity of the isolated products.

关 键 词：Meso-四(4-O-取代苯基)卟啉化合物 合成 索氏提取器 纯化 

分 类 号：O626[理学—有机化学]