参脉注射液联合西药治疗冠心病合并慢性心力衰竭气阴两虚证临床研究  

Clinical Study on Shenmai Injection Combined with Western Medicine for Coronary Heart Disease Complicated with Chronic Heart Failure with Dual Deficiency of Qi and Yin Syndrome

作　　者：纪青 雷李美[1] JI Qing;LEI Limei

机构地区：[1]丽水市人民医院,浙江丽水323000

出　　处：《新中医》2021年第24期61-64,共4页New Chinese Medicine

摘　　要：目的:观察参脉注射液联合西药治疗冠心病合并慢性心力衰竭(CHF)气阴两虚证的临床疗效。方法:选择82例冠心病合并CHF气阴两虚证患者,按不同治疗方法分为治疗组42例与对照组40例。对照组给予西药治疗,治疗组给予参脉注射液联合西药治疗,2组均连续治疗14 d。比较2组临床疗效;比较2组治疗前后中医证候积分、心功能指标及超敏C-反应蛋白(hs-CRP)、氨基末端脑钠尿肽前体(NT-proBNP)水平。结果:治疗组总有效率为92.86%,高于对照组的75.00%(P<0.05)。治疗后,2组中医证候积分均较治疗前降低,治疗组中医证候积分低于对照组,差异均有统计学意义(P<0.05);2组每搏输出量(SV)、心排血量(CO)及左室射血分数(LVEF)均较治疗前增大,治疗组SV、CO、LVEF均大于对照组,差异均有统计学意义(P<0.05);2组hs-CRP、NT-proBNP水平均较治疗前降低,治疗组hs-CRP、NT-proBNP水平均低于对照组,差异均有统计学意义(P<0.05)。结论:参脉注射液联合西药治疗冠心病合并CHF气阴两虚证疗效确切,可有效缓解患者的临床症状,减少心肌损伤,减轻机体炎症反应。Objective:To observe the clinical effect of Shenmai injection combined with western medicine for coronary heart disease complicated with chronic heart failure(CHF)with dual deficiency of qi and yin syndrome.Methods:A total of 82 cases of patients with coronary heart disease complicated with CHF with dual deficiency of qi and yin syndrome were divided into the treatment group and the control group according to different treatment methods,with 42 and 40 cases in each group respectively.The control group was given western medicine treatment,and the treatment group was treated with Shenmai injection combined with western medicine.Both groups were treated for 14 days.The clinical effects in the two groups were compared.Before and after treatment,Chinese medicine syndrome scores,heart function indexes and the levels of serum high-sensitivity C-reactive protein(hs-CRP)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in the two groups were compared.Results:The total effective rate was 92.86%in the treatment group,higher than that of 75.00%in the control group(P<0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in treatment group was lower than that in the control group,differences being significant(P<0.05).Stroke volume(SV),cardiac output(CO)and left ventricular ejection fraction(LVEF)in the two groups were increased when compared with those before treatment,and SV,CO and LVEF in treatment group were higher than those in the control group,differences being significant(P<0.05).The levels of hs-CRP and NT-proBNP in the two groups were decreased when compared with those before treatment,and the levels of hs-CRP and NT-proBNP in treatment group were lower than those in the control group,differences being significant(P<0.05).Conclusion:Shenmai injection combined with western medicine has a definite curative effect in treating coronary heart disease combined with CHF with dual deficiency of qi and yin syndrome,which can effecti

关 键 词：冠心病 慢性心力衰竭 气阴两虚证 参脉注射液 中医证候 心功能 超敏C-反应蛋白 氨基末端脑钠尿肽前体 

分 类 号：R541[医药卫生—心血管疾病]