氟桂利嗪联合血塞通治疗偏头痛有效性和安全性Meta分析  

Efficacy and Safety of Flunarizine Combined with Xuesaitong in the Treatment of Migraine:A Meta-Analysis

作　　者：王冰 刘欣欣 冯亚楠 赵俐 WANG Bing;LIU Xinxin;FENG Yanan;ZHAO Li(Hebei Center for Pharmacovigilance,Shijiazhuang,Hebei,China 050090)

机构地区：[1]河北省药物警戒中心,河北石家庄050090

出　　处：《中国药业》2022年第2期109-115,共7页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2021218]。

摘　　要：目的评价氟桂利嗪联合血塞通治疗偏头痛的有效性和安全性。方法计算机检索中国期刊全文数据库(CNKI)、PubMed和维普数据库,检索时限为各数据库自建库起至2021年2月24日,收集氟桂利嗪联合血塞通治疗偏头痛的随机对照试验(RCT),提取资料,采用Cochrane偏倚风险评估工具评估文献质量,采用Rev Man 5.3统计学软件进行Meta分析。结果最终纳入29篇文献,共2867例患者;与对照组比较,观察组的总有效率[RR=1.24,95%CI(1.20,1.28),P<0.00001]显著升高,发作次数[MD=-6.17,95%CI(-8.19,-4.15),P<0.00001]显著减少,发作持续时间[MD=-2.86,95%CI(-3.82,-1.89),P<0.00001]显著缩短,疼痛程度[MD=-1.42,95%CI(-1.47,-1.37),P<0.00001]显著减轻,两组患者的不良反应发生率相当[RR=0.85,95%CI(0.57,1.26),P=0.42]。结论氟桂利嗪联合血塞通治疗偏头痛的疗效优于前者单用,且安全性较高,但该研究中纳入文献的数量较小、质量较低,需更高质量的RCT予以验证。Objective To evaluate the efficacy and safety of flunarizine combined with Xuesaitong in the treatment of migraine.Methods The CNKI,PubMed and VIP databases were electronically searched from inception to February 24th,2021 to collect the randomized controlled trials(RCTs)of flunarizine combined with Xuesaitong in the treatment of migraine.Data were extracted to evaluate the quality of studies by using the Cochrane bias risk assessment tool.The Meta-analysis was performed by using the Rev Man 5.3 software.Results A total of 29 studies involving 2867 patients were included.Compared with those in the control group,the total effective rate[RR=1.24,95%CI(1.20,1.28),P<0.00001]in the observation group increased significantly,while the times of attacks[MD=-6.17,95%CI(-8.19,-4.15),P<0.00001]in the observation group were significantly decreased,the duration of attacks[MD=-2.86,95%CI(-3.82,-1.89),P<0.00001]in the observation group were significantly shortened,and the degree of pain[MD=-1.42,95%CI(-1.47,-1.37),P<0.00001]in the observation group were significantly reduced.The incidence of adverse reactions in the two groups was similar[RR=0.85,95%CI(0.57,1.26),P=0.42].Conclusion The efficacy and safety of flunarizine combined with Xuesaitong in the treatment of migraine are better than that of flunarizine.However,there are few studies with low quality included in this study,which needs to be verified by more high-quality RCTs.

关 键 词：氟桂利嗪 血塞通 偏头痛 有效性 安全性 META分析 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]