老年急性髓系白血病患者减低剂量化疗的疗效及预后影响因素分析  

Analysis of the Efficacy and Prognostic Factors of Reduced-dose Chemotherapy in Elderly Patients with Acute Myeloid Leukemia

作　　者：陈玲玲[1] 蔡亚云[2] CHEN Lingling;CAI Yayun(Department of Hematology,Rudong County People's Hospital,Rudong,Jiangsu Province,226400 China;Department of Hematology,Rugao People's Hospital,Rugao,Jiangsu Province,226300 China)

机构地区：[1]如东县人民医院血液科,江苏如东226400 [2]如皋市人民医院血液科,江苏如皋226300

出　　处：《中外医疗》2021年第33期49-52,共4页China & Foreign Medical Treatment

摘　　要：目的分析急性髓系白血病老年患者采取低剂量化疗的临床效果及对患者产生的影响,归纳分析预后相关影响因素。方法随机选取2016年1月—2021年6月于如东县人民医院和如皋市人民医院接受化疗治疗的急性髓系白血病老年患者70例进行研究,根据双盲法对患者进行随机分组,对照组患者以标准剂量进行化疗,观察组患者以低剂量实施化疗,观察对比两组患者治疗效果,统计各组患者化疗后不良反应发生概率。归纳整理影响患者预后的相关因素。结果两组患者治疗总有效率分别为51.43%、57.14%,两组对比差异无统计学意义(χ^(2)=0.230,P>0.05)。观察组患者化疗后不良反应发生率25.71%低于对照组,差异有统计学意义(χ^(2)=5.952,P<0.05)。相关因素分析结果显示,年龄、体能状况、初始白细胞计数、残留病灶WTI基因均为影响患者预后的相关因素,而性别、疾病分型、初始血红蛋白水平与预后无直接影响。结论急性髓系白血病老年患者可通过减低剂量化疗达到治疗效果,安全性良好,需要注意的是,患者年龄、体能状态等因素均对预后造成直接影响,应重点关注,从而保障化疗效果,延长患者生存时间。Objective To analyze the clinical effects of low-dose chemotherapy in elderly patients with acute myeloid leukemia and its impact on the patients,and to summarize and analyze the prognostic factors.Methods Randomly selected 70 elderly patients with acute myeloid leukemia who received chemotherapy at Rudong County People's Hospital and Rugao City People's Hospital from January 2016 to June 2021 were selected for study.The patients were randomized according to the double-blind method,and the control group patients was carried out at standard doses,and patients in the observation group were given chemotherapy at low doses.The treatment effects of the two groups were observed and compared,and the probability of adverse reactions after chemotherapy in each group was counted.Summarize and sort out the relevant factors that affect the prognosis of patients.Results The total effective rates of the two groups were 51.43%and 57.14%,respectively,there was no significant difference between the two groups(χ^(2)=0.230,P>0.05).The incidence of adverse reactions after chemotherapy in the observation group was 25.71%,which was significantly lower than that in the control group,and the difference was statistically significant(χ^(2)=5.952,P<0.05).The results of correlation factor analysis show that age,physical fitness,initial white blood cell count,and residual disease WTI gene were all related factors that affect the prognosis of patients,while gender,disease type,initial hemoglobin level and prognosis had no direct effect.Conclusion Elderly patients with acute myeloid leukemia can achieve therapeutic effects through reduced-dose chemotherapy with good safety.It should be noted that factors such as patients'age and physical status have a direct impact on the prognosis,and attention should be paid to ensure the effect of chemotherapy and prolong the patient's survival time.

关 键 词：老年急性髓系白血病 低剂量化疗 预后影响因素 分析 

分 类 号：R473[医药卫生—护理学]