高危型HPVE6/E7mRNA检测在新疆维吾尔族妇女宫颈病变分层管理中的应用价值  

Application Value of High-risk HPVE6/E7mRNA Detection in the Stratified Management of Cervical Lesions in Uyghur Women in Xinjiang

作　　者：朱行行 吕锡芳[1] ZHU Xingxing;LYU Xifang(Department of Gynecology,First Affiliated Hospital of School of Medicine,Shihezi University,Shihezi,Xinjiang,Uygur Autonomous Regin,832000 China)

机构地区：[1]石河子大学医学院第一附属医院妇科,新疆石河子832000

出　　处：《中外医疗》2021年第34期5-9,共5页China & Foreign Medical Treatment

基　　金：2019年石河子大学自主资助支持校级科研项目(ZZZC201953A)。

摘　　要：目的分析高危型HPV(HR-DNA)E6/E7mRNA检测在新疆维吾尔族妇女宫颈病变分层管理中的应用价值。方法随机选取2019年10月—2021年10月在该院妇科门诊行TCT检查为阳性(≥ASCUS)同时HC2初筛阳性的维吾尔族患者共100例为研究对象,依据随机数表法将其中50例归为观察组(予以HR-HPVE6/E7mRNA及HPV DNA联合检测),余下50例归为对照组(予以HPV DNA检测),将宫颈活检病理学检查结果作为金标准,观察两组不同细胞学与组织学分级中的阳性率、筛查费用及阴道镜转诊率情况。结果两组NILM、LSIL、HSIL和宫颈癌中的阳性率对比,差异无统计学意义(P>0.05),观察组ASCUS中的阳性率为26.67%低于对照组的73.33%,差异有统计学意义(χ^(2)=6.533,P=0.011)。两组慢性宫颈炎、CINⅡ级、CINⅢ级及宫颈浸润癌中的阳性率对比,差异无统计学意义(P>0.05),观察组CINⅠ级中的阳性率为21.43%低于对照组78.57%,差异有统计学意义(χ^(2)=5.316,P=0.021)。伴随细胞学和组织学分级升高,两组阳性率呈现不断升高趋势。观察组筛查费用为(1254.50±258.60)元低于对照组(1735.20±274.00)元,差异有统计学意义(t=9.022,P<0.001);观察组筛查的阴道镜转诊率为8.00%低于对照组24.00%,差异有统计学意义(χ^(2)=4.762,P=0.029)。结论HR-HPVE6/E7mRNA检测在新疆维吾尔族妇女宫颈病变分层管理中有着重要应用价值,可当作二线筛查指标,能有效检出高级上皮内瘤变和宫颈癌,使一过性的HPV感染检出率降低,减少对于疾病严重度误判,降低患者的筛查费用及阴道镜转诊率。Objective To analyze the application value of high-risk HPV(HR-DNA)E6/E7mRNA detection in the stratified management of cervical lesions in Uyghur women in Xinjiang.Methods A total of 100 Uyghur patients with positive TCT test(≥ASCUS)and positive HC2 preliminary screening at the gynecological clinic of the hospital from October 2019 to October 2021 were randomly selected as the research objects.According to the random number table method,50 of them were classified as the observation group(HR-HPVE6/E7mRNA and HPV DNA combined detection),the remaining 50 cases were classified as the control group(for HPV DNA detection),the pathological examination results of cervical biopsy were used as the gold standard,and the two groups were observed in different cytological and histological grades of positive rate,screening cost,and colposcopy referral rate.Results There was no statistically significant difference in the positive rates of the two groups in NILM,LSIL,HSIL and cervical cancer(P>0.05).The positive rate in ASCUS of the observation group was 26.67%lower than that of the control group 73.33%,the difference was statistically significant(χ^(2)=6.533,P=0.011).There was no statistically significant difference in the positive rates of chronic cervicitis,CIN Ⅱ,CIN Ⅲ,and cervical invasive cancer between the two groups(P>0.05).The positive rate of CIN Ⅰ in the observation group was 21.43%lower than that in the control group 78.57%,the difference was statistically significant(χ^(2)=5.316,P=0.021).With the increase of cytology and histology grades,the positive rate of the two groups showed a rising trend.The screening cost of the observation group was(1254.50±258.60)yuan lower than that of the control group(1735.20±274.00)yuan,the difference was statistically significant(t=9.022,P<0.001);the colposcopy referral rate for screening in the observation group was 8.00%lower than the control group 24.00%,the difference was statistically significant(χ^(2)=4.762,P=0.029).Conclusion HR-HPVE6/E7mRNA detection has important a

关 键 词：新疆维吾尔族 宫颈病变 分层管理 高危型HPVE6/E7mRNA检测 

分 类 号：R711[医药卫生—妇产科学]