干扰素刺激基因抗HBV感染的研究进展  

Research advances in interferon-stimulated genes in treatment of hepatitis B virus infection

作　　者：练韵文 郑杏容 吴和维 高志良[1] 陈希瑶 谢婵[1] LIAN Yunwen;ZHENG Xingrong;WU Hewei;GAO Zhiliang;CHEN Xiyao;XIE Chan(Department of Infectious Diseases,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]中山大学第三附属医院传染病科,广州510630

出　　处：《临床肝胆病杂志》2022年第1期180-186,共7页Journal of Clinical Hepatology

基　　金：中山大学5010常规项目(2018009)。

摘　　要：HBV感染与肝硬化、肝癌及肝衰竭等不良事件密切相关,严重威胁人类健康。聚乙二醇干扰素是治疗慢性乙型肝炎不可或缺的药物,干扰素刺激基因与多种病毒感染相关,但与乙型肝炎的关系及干扰素治疗乙型肝炎后的预测作用仍较少被提及。介绍了干扰素治疗慢性乙型肝炎相关的预测因素,总结了干扰素刺激基因与乙型肝炎的关系及其预测作用,为临床工作及基础研究提供参考。Hepatitis B virus(HBV)infection is closely associated with the adverse events such as liver cirrhosis,liver cancer,and liver failure and remains a serious threat to human health.Pegylated interferon is an indispensable drug for the treatment of chronic hepatitis B(CHB),and interferon-stimulated genes are associated with a variety of viruses,but few studies have mentioned their association with hepatitis B and their predictive effect after the treatment of hepatitis B with interferon.This article introduces the predictive factors for interferon treatment of CHB and summarizes the association of interferon-stimulated genes with hepatitis B and their predictive effect,so as to provide a reference for clinical work and basic research.

关 键 词：乙型肝炎 慢性 干扰素类 干扰素刺激基因 

分 类 号：R512.62[医药卫生—内科学]