靶向自噬缓解肝缺血再灌注损伤的研究进展  

Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury

作　　者：李振 王科 王凯强 俞科贤[2] LI Zhen;WANG Ke;WANG Kaiqiang;YU Kexian(Graduate School of Qinghai University,Xining 810016,China;School of Traditional Chinese Medicine,Medical College of Qinghai University,Xining 810016,China)

机构地区：[1]青海大学研究生院,西宁810016 [2]青海大学医学院中医学院,西宁810016

出　　处：《临床肝胆病杂志》2022年第1期210-214,共5页Journal of Clinical Hepatology

基　　金：国家中医药管理局——全国中医药创新骨干人才培训项目(国中医药人教函〔2019〕128号);教育部“春晖计划”科技项目(Z2017038)。

摘　　要：肝缺血再灌注损伤(HIRI)是肝切除和肝移植术后常见的临床问题,是导致移植术后肝功能障碍和肝功能衰竭的主要原因。近年来,自噬介导的途径成为缓解HIRI的研究热点。自噬是指细胞通过将大量细胞质、受损细胞器等底物运输到溶酶体内进行消化降解以不断更新重塑再利用细胞的过程。本文从基因、蛋白、信号通路、炎症反应、氧化应激反应、线粒体及内质网应激等方面总结了靶向自噬途径缓解HIRI相关机制的研究进展,并围绕研究中存在的问题进行了讨论和展望,以期为今后通过靶向自噬途径缓解HIRI的研究提供理论支持。Hepatic ischemia-reperfusion injury(HIRI)is a common clinical problem after hepatectomy and liver transplantation and is the main cause of liver dysfunction and liver failure after transplantation.In recent years,autophagy-mediated pathways have become a research hotspot in alleviating HIRI.Autophagy refers to the process in which a large number of substrates such as cytoplasm and damaged organelles are transported into lysosomes for digestion and degradation,so as to constantly renew,reshape,and reuse cells.This article summarizes the research advances in the mechanism of targeting autophagy to alleviate HIRI from the aspects of gene,protein,signaling pathway,inflammatory response,oxidative stress,and mitochondrial and endoplasmic reticulum stress,as well as existing problems and prospects in research,in order to provide theoretical support for the future research on alleviating HIRI by targeting autophagy.

关 键 词：自噬 再灌注损伤 氧化性应激 

分 类 号：R657.3[医药卫生—外科学]