循环外泌体在心血管疾病中作用的研究进展  

Research progress on the role of circulating exosome in cardiovascular disease

作　　者：刘伟[1] 官红权 丁嘉星 陈志坚[1] LIU Wei;GUAN Hongquan;DING Jiaxing;CHEN Zhijian(Department of Cardiovascular Medicine,Union Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院心血管内科,湖北武汉430022

出　　处：《老年医学研究》2021年第6期35-39,共5页Geriatrics Research

基　　金：国家自然科学基金资助项目(81770330,表达下调的MicroRNA-130a过度激活心肌细胞自噬致心肌梗死后室性心律失常的研究)。

摘　　要：近些年来,心血管疾病的发展形势日益严峻,我国心血管疾病患病率和病死率持续不断攀升。循环外泌体是细胞释放入血液循环的30~150 nm的双层脂质囊泡,是信息传递的媒介,可以通过血液循环到达远距离的靶组织器官,作用于靶细胞。循环外泌体广泛参与心血管疾病的发生发展过程,例如心力衰竭、冠心病、急性心肌梗死、高血压和心肌病等。In recent years,the development of cardiovascular disease is becoming more and more serious.The prevalence and mortality of cardiovascular disease continue to rise in China.Circulating exosome is a bilayer lipid vesicle with a diameter of 30-150 nm released into blood circulation by cells.As a medium for information transfer,it can reach long-distance target tissues and organs through blood circulation and act on target cells.Circulating exosome is widely involved in the occurrence and development of cardiovascular disease,such as heart failure,coronary heart disease,acute myocardial infarction,hypertension and cardiomyopathy。

关 键 词：循环外泌体 心血管疾病 MIRNA 生物标志物 

分 类 号：R714.252[医药卫生—妇产科学]