联用双歧杆菌四联活菌片与单用蒙脱石散治疗小儿腹泻的疗效及安全性比较  

Efficacy and safety evaluation of bifidobacterium tetralogy tablet combined with montmorillonite powder in the treatment of infantile diarrhea

作　　者：刘盼盼[1] LIU Panpan(Bone and Joint Sports Bone and Soft Tissue Tumor Ward,Bone Surgery,Shengjing Hospital of China Medical University,Shenyang 110016,China)

机构地区：[1]中国医科大学附属盛京医院骨外科骨关节运动与软组织肿瘤病房,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2021年第12期1334-1338,共5页Journal of Shenyang Pharmaceutical University

摘　　要：目的对双歧杆菌四联活菌片与蒙脱石散联合治疗小儿腹泻进行疗效及安全性评价。方法选择2012年7月-2020年7月期间的300例小儿腹泻疾病患者,其中包含100例细菌性腹泻,100例病毒性腹泻及100例非感染性腹泻,并依据处理方式分为对照组与观察组。对照组采取蒙脱石散治疗,观察组采取双歧杆菌四联活菌片+蒙脱石散治疗。结果观察组小儿的大便次数、体温、腹痛与呕吐复常用时均明显短于对照组小儿,治疗总有效率95.33%明显高于对照组的85.33%,差异有统计学意义(P<0.05);观察组与对照组小儿胃肠道等不良反应接近,差异没有统计学意义(P>0.05)。在细菌性腹泻中,观察组治疗后的血清C-反应蛋白水平与白细胞计数低于对照组;在病毒性腹泻中,观察组治疗后轮状病毒转阴率高于对照组;在非感染性腹泻中,观察组治疗后血清IL-6、IL-17、IgA水平低于对照组,且均有统计学意义(P<0.05)。结论双歧杆菌四联活菌片、蒙脱石散联合用药可以提高小儿腹泻的治疗效果,促进患儿康复。Objective To evaluate the value of combined treatment of bifidobacterium tetralogy tablets and montmorillonite powder for infantile diarrhea disease.Methods A total of 300 pediatric patients with diarrhea from July 2012 to July 2020 were selected,including 100 cases of bacterial diarrhea,100 cases of viral diarrhea and 100 cases of non-infectious diarrhea,and were randomly divided into the control group and the observation group.The control group was treated with montmorillonite powder,the children in the observation group were treated with bifidobacterium tetralogy tablets montmorillonite powder.Results The time of the number of stools,body temperature,abdominal pain and vomiting restoring to normal in the observation group were significantly shorter than those in the control group,and the total effective rate(95.33%) was significantly higher than that in the control group(85.33%),with statistical significance(P<0.05).The adverse reactions of gastrointestinal tract were similar between the observation group and the control group,and the difference was not statistically significant(P>0.05).In bacterial diarrhea,the serum C-reactive protein level and white blood cell count in the observation group were lower than those in the control group after treatment.In viral diarrhea,the negative rate of rotavirus in the observation group was higher than that in the control group.In non-infectious diarrhea,the levels of serum IL-6,IL-17 and IgA in the observation group were lower than those in the control group after treatment,and all of them were statistically significant(P<0.05).Conclusion The combination of bifidobacterium tetralogy tablets and montmorillonite powder can improve the treatment effect of pediatric diarrhea and promote the recovery of children.

关 键 词：双歧杆菌四联活菌片 蒙脱石散 小儿腹泻 治疗效果 不良反应 症状消失时间 

分 类 号：R969.4[医药卫生—药理学]