美罗培南与亚胺培南-西司他丁治疗重症肺部感染的效果比较  

Comparison of Effect of Meropenem and Imipenem-Cilastatin in the Treatment of Severe Lung Infection

作　　者：翟磊磊 ZHAI Lei-lei(Department of Clinical Medicine,Chinese Medicine Hospital of Puyang,Puyang 457000,Henan Province,China)

机构地区：[1]濮阳市中医医院临床医药科,河南濮阳457000

出　　处：《罕少疾病杂志》2022年第2期34-35,45,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的比较美罗培南和亚胺培南-西司他丁治疗重症肺部感染的临床疗效。方法将60例在我院进行诊治的重症肺部感染患者按随机数字表法分为对照组(n=30)与观察组(n=30)。分别给予美罗培南和亚胺培南-西司他丁进行治疗,对两组的临床病症消退时间、临床有效率、细菌清除率及血清炎症介质水平进行对比。结果治疗结束后,观察组的咳嗽、肺部啰音、发热的消退时间均短于对照组,差异具有统计学意义(P<0.05);观察组临床有效率为86.6%,高于对照组的60.0%,差异具有统计学意义(χ^(2)值=5.455,P<0.05);观察组细菌清除率为90.0%,高于对照组的76.7%,差异具有统计学意义(χ^(2)值=4.812,P<0.05);两组患者的炎症因子IL-6、IL-8、TNF-α的表达水平有了明显的改善,且观察组显著低于对照组患者,差异具有统计学意义(P<0.05)。结论对于重症肺部感染,美罗培南缩短病症消退时间、提高临床有效率和细菌清除率、减轻炎症反应方面的效果要优于亚胺培南-西司他丁。Objective To compare the clinical efficacy of meropenem and imipenem-cilastatin in the treatment of severe lung infection. Methods Sixty patients with severe lung infection who were diagnosed and treated in our hospital were divided into control group(n=30) and observation group(n=30) according to the random number table method. Meropenem and imipenem-cilastatin were given respectively for treatment,and the regression times of clinical symptoms, clinical effective rate, bacterial clearance rate and levels of serum inflammatory mediators were compared between the two groups. Results After the end of treatment, the regression times of cough, lung rales and fever of observation group were shorter than those of control group(P<0.05). The clinical effective rate with 86.6% in observation group was higher than 60.0% in control group(2 =5.455, P<0.05). The bacterial clearance rate was higher in observation group than that in control group(90.0% vs. 76.7%)(2 =4.812,P<0.05). The expression levels of inflammatory factors such as IL-6, IL-8 and TNF-α in the two groups of patients were significantly improved, and the levels of observation group were significantly lower than those of control group(P<0.05). Conclusion For severe lung infection, meropenem is better than imipenem-cilastatin in terms of shortening the regression times of symptoms, improving clinical effective rate and bacterial clearance rate and relieving inflammatory response.

关 键 词：美罗培南 亚胺培南司他丁 重症肺部感染 

分 类 号：R978.1[医药卫生—药品] R563[医药卫生—药学]