High-resolution two-photon polymerization:the most versatile technique for the fabrication of microneedle arrays  

作　　者：Zahra Faraji Rad Philip D.Prewett Graham J.Davies 

机构地区：[1]School of Mechanical and Elearical Engineering,University of Southern Queensland,Springfield Central,QLD 4300,Australia [2]Department of Mechanical Engineering,University of Birmingham,Birmingham B152TT,UK [3]Oxacus Ltd,Dorchester-on-Thames 0X107HN,UK [4]Faculty of Engineering,UNSW Australia,Kensington,NSW 2052,Australia [5]College of Engineering and Physical Sciences,School of Engineering,University of Birmingham,Birmingham B152TT,UK

出　　处：《Microsystems & Nanoengineering》2021年第5期1-17,共17页微系统与纳米工程（英文）

摘　　要：Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring purposes.Microneedles are manufactured using a variety of additive and subtractive micromanufacturing techniques.In the last decade,much attention has been paid to using additive manufacturing techniques in both research and industry,such as 3D printing,fused deposition modeling,inkjet printing,and two-photon polymerization(2PP),with 2PP being the most flexible method for the fabrication of microneedle arrays.2PP is one of the most versatile and precise additive manufacturing processes,which enables the fabrication of arbitrary three-dimensional(3D)prototypes directly from computer-aided-design(CAD)models with a resolution down to 100 nm.Due to its unprecedented flexibility and high spatial resolution,the use of this technology has been widespread for the fabrication of bio-microdevices and bio-nanodevices such as microneedles and microfluidic devices.This is a pioneering transformative technology that facilitates the fabrication of complex miniaturized structures that cannot be fabricated with established multistep manufacturing methods such as injection molding,photolithography,and etching.Thus,microstructures are designed according to structural and fluid dynamics considerations rather than the manufacturing constraints imposed by methods such as machining or etching processes.This article presents the fundamentals of 2PP and the recent development of microneedle array fabrication through 2PP as a precise and unique method for the manufacture of microstructures,which may overcome the shortcomings of conventional manufacturing processes.

关 键 词：resolution NEEDLE ADDITIVE 

分 类 号：O572[理学—粒子物理与原子核物理]