Continuous monitoring of diabetes with an integrated microneedle biosensing device through 3D printing  

作　　者：Yiqun Liu Qi Yu Xiaojin Luo Li Yang Yue Cui 

机构地区：[1]School of Materials Science and Engineering,Peking University,100871 Beijing,P.R.China [2]Renal Division,Peking University Institute of Nephrology,Peking University First Hospital,100034 Beijing,P.R.China

出　　处：《Microsystems & Nanoengineering》2021年第5期161-172,共12页微系统与纳米工程（英文）

基　　金：the National Natural Science Foundation of China(No.52072007,No.91742205,and No.81625004);National Key R&D Program of China(No.2018YFB1307301)for financial support.

摘　　要：Diabetes is a prevalent chronic metabolic disease with multiple clinical manifestations and complications,and it is among the leading causes of death.Painless and continuous monitoring of interstitial glucose is highly desirable for diabetes management.Here we unprecedentedly show continuous monitoring of diabetes with an integrated microneedle biosensing device.The device was manufactured with a 3D printing process,a microfabrication process,an electroplating process,and an enzyme immobilization step.The device was inserted into the dermis layer of mouse skin and showed accurate sensing performance for monitoring subcutaneous glucose levels in normal or diabetic mice.The detection results were highly correlated with those obtained from a commercial blood glucose meter.We anticipate that the study could open exciting avenues for monitoring and managing diabetes,alongside fundamental studies of subcutaneous electronic devices.

关 键 词：NEEDLE DIABETES PRINTING 

分 类 号：R587.1[医药卫生—内分泌] TP212.3[医药卫生—内科学]