基于组织工程技术修复节段性气管缺损的研究进展  

Research progress of circumferential tracheal reconstruction via tissue-engineered trachea

作　　者：徐勇[1] 高二击 段亮[1] 姜格宁[1] Xu Yong;Gao Erji;Duan Liang;Jiang Gening(Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China)

机构地区：[1]同济大学附属上海市肺科医院胸外科,上海200433

出　　处：《中华外科杂志》2022年第1期104-109,共6页Chinese Journal of Surgery

基　　金：国家自然科学基金(81570089,82070022,81970014);上海市自然科学基金(19ZR1442600)。

摘　　要：近年来,基于组织工程技术修复节段性气管缺损领域出现了大量新的支架材料、制备技术和构建理念,丰富了组织工程气管的临床转化前景。脱细胞、三维打印、静电纺丝和细胞膜片等技术使组织工程气管软骨化日趋稳定成熟,上皮细胞种植或上皮细胞膜片移植加速了组织工程气管的上皮化进程,血供丰富的肌肉筋膜等组织的包裹联合带血管蒂移植修复策略的可靠性也获得了证实。如何整合上述方案,同时实现组织工程气管软骨、上皮及血管组织再生,以期最终实现节段性气管功能重建,尚需进一步研究。Tissue engineering,as a new technology,provides a new avenue for the reconstruction of circumferential tracheal defects,which has always been a tremendous challenge for surgeons around the world.Recently,technologies such as decellularization,3-dimensional printing,electrospinning and cell sheet have significantly enhanced the chondrification.Implantation of epithelial cells or transplantation of epithelial cell sheets also has accelerated the process of epithelialization.And pedicle muscle flap proved to be a reliable strategy for vascularization of tissue-engineered trachea.But it is still a huge challenge to achieve circumferential tracheal functional reconstruction.The key difficulty lies in how to simultaneously realize the functional regeneration of cartilage,blood vessels and epithelial tissues of tissue-engineered trachea.Therefore,how to integrate the above schemes and finally realize segmental tracheal reconstruction needs further research.This article reviews the research progress of repairing circumferential tracheal defects based on tissue engineering technology.

关 键 词：气管 组织工程 修复外科手术 

分 类 号：R653[医药卫生—外科学]