急性感染性心内膜炎患者治疗过程中CRP/HGB、ESR、Gal-3动态变化情况分析  

Dynamic Changes of CRP/HGB,ESR and Gal-3 in Patients with Acute Infective Endocarditis during Treatment

作　　者：王颖 杨鲲 何勇 WANG Ying;YANG Kun;HE Yong(Department of Cardiology,Shaanxi Provincial General Hospital of Armed Police,Xi'an Shaanxi,710054)

机构地区：[1]武警陕西省总队医院心内科,陕西西安710054

出　　处：《医学临床研究》2021年第12期1815-1817,1821,共4页Journal of Clinical Research

摘　　要：【目的】探讨急性感染性心内膜炎(AIE)患者治疗过程中C反应蛋白(CRP)与血红蛋白(HGB)比值(CRP/HGB)、血沉(ESR)、半乳糖凝集素-3(Gal-3)动态变化情况。【方法】选取本院收治的147例AIE患者,根据入院后1个月内生存情况将其分为死亡组(n=23)、生存组(n=124)。比较两组治疗前、治疗1周后、治疗2周后CRP/HGB、ESR、Gal-3、白细胞计数(WBC)、降钙素原(PCT)水平,采用Logistic回归方程分析预后的相关影响因素,采用受试者工作特征曲线(ROC)分析各指标预测预后价值。【结果】治疗1周、2周后,死亡组血清CRP/HGB、ESR、Gal-3、WBC、PCT水平与治疗前比较,差异无统计学意义(P>0.05);生存组上述指标均低于治疗前,死亡组高于生存组,差异有统计学意义(P<0.05)。Logistic回归方程分析显示,治疗1周、2周后CRP/HGB、ESR、Gal-3水平是影响患者预后的相关因素(P<0.05)。治疗2周后CRP/HGB、ESR、Gal-3预测预后的AUC分别为0.827、0.844、0.836(P<0.05),CRP/HGB+ESR+Gal-3预测预后的AUC为0.949(P<0.05)。【结论】治疗过程中监测CRP/HGB、ESR、Gal-3水平对评估AIE患者预后具有重要意义,可辅助临床预测患者预后转归。【Objective】To investigate the dynamic changes of C-reactive protein(CRP)to hemoglobin(Hgb)ratio(CRP/Hgb),erythrocyte sedimentation rate(ESR)and galactose lectin-3(Gal-3)in patients with acute infective endocarditis(AIE).【Methods】A total of 147 patients with AIE was selected.According to the survival within 1 month after admission,they were divided into death group(n=23)and survival group(n=124).The levels of CRP/HGB,ESR,Gal-3,white blood cell count(WBC)and procalcitonin(PCT)were compared between the two groups before treatment,1 week after treatment and 2 weeks after treatment.The relevant influencing factors of prognosis were analyzed by logistic regression equation,and the working characteristic curve of subjects was used(ROC)the prognostic value of each index was analyzed.【Results】After 1 and 2 weeks of treatment,the levels of serum CRP/HGB,ESR,Gal-3,WBC and PCT in the death group were not significantly different from those before treatment(P>0.05);the above indexes in the survival group were lower than those before treatment,and the death group was higher than that in the survival group(P<0.05).Logistic regression equation analysis showed that the levels of CRP/HGB,ESR and Gal-3 after 1 and 2 weeks of treatment were related factors affecting the prognosis of patients(P<0.05).The AUCs of CRP/HGB,ESR and Gal-3 after 2 weeks of treatment were 0.827,0.844 and 0.836 respectively(P<0.05),and the AUC of CRP/HGB+ESR+Gal-3 was 0.949(P<0.05).【Conclusion】Monitoring the levels of CRP/HGB,ESR and Gal-3 during treatment is of great significance to evaluate the prognosis of AIE patients,and can assist in predicting the prognosis of AIE patients.

关 键 词：感染/病因学 心内膜炎/病因学 急性病 C反应蛋白质 血沉 半乳糖凝集素3 

分 类 号：R542.42[医药卫生—心血管疾病]