急性期川崎病患儿血脂改变及与炎症指标的相关性研究  

Changes of serum lipids and the correlation between serum lipids and inflammatory indexes in children with acute Kawasaki disease

作　　者：吴丽平 青秀 李刚 刘东 刘斌 WU Li-Ping;QING Xiu;LI Gang;LIU Dong;LIU Bin(Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Luzhou 646000, China)

机构地区：[1]西南医科大学附属医院儿科,四川省出生缺陷临床医学研究中心,四川泸州646000

出　　处：《实用医院临床杂志》2022年第1期139-142,共4页Practical Journal of Clinical Medicine

摘　　要：目的分析川崎病(kawasaki disease,KD)患儿血脂代谢的变化及其与炎症指标的相关性,探讨其在KD患儿中的临床意义。方法回顾性收集86例KD患儿、63例严重感染患儿、46例轻度感染患儿和44例健康儿童的血脂检测结果;同时收集KD患儿是否不完全性川崎病、是否8周内冠状动脉扩张,以及血常规检测结果;比较4组儿童的血脂差异并对KD患儿的血脂和炎症指标进行相关性分析。结果总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、非高密度脂蛋白胆固醇(non-HDL-C)水平和APOB/LDL-C在4组儿童间比较差异均有统计学意义(P<0.05);KD患儿的HDL-C和APOA1水平与C反应蛋白(CRP)水平成负相关(r=-0.340、-0.383,P<0.05)。结论急性期KD患儿存在血脂代谢紊乱,且与炎症密切相关。Objective To analyze the changes of lipid metabolism and the correlation between serum lipids and inflammatory indexes in children with Kawasaki disease(KD),and explore the clinical significance of dyslipidemia in KD children.Methods The study included 86 children with KD,63 children with severe infection,46 children with mild infection,and 44 healthy children.Results of the levels of blood lipids of all children were collected retrospectively.For KD children,additional information included whether they suffered from incomplete Kawasaki disease,whether coronary arteries were diluted within 8 weeks,and peripheral blood cells index.The differences of blood lipids levels in the four groups were compared and the correlation between blood lipids and inflammatory indexes in children with KD was analyzed.Results There were significant differences in total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,apolipoprotein A1,apolipoprotein B,non-high density lipoprotein cholesterol and apolipoprotein B/low density lipoprotein cholesterol among the 4 groups(all P<0.05).The levels of high density lipoprotein cholesterol and apolipoprotein A1 were negatively correlated with C-reactive protein(CRP)level in children with KD(r=-0.340 and-0.383,respectively,all P<0.05).Conclusion In the acute phase of KD,the sick children have dyslipidemia,and the levels of serum lipids are closely related to inflammation.

关 键 词：血脂异常 炎症指标 川崎病 

分 类 号：R725.4[医药卫生—儿科]