Ulinastatin Exerts the Protective Effects of Lung by UpRegulating Aquaporins Expression in a Two-Hit Porcine Model of Acute Respiratory Distress Syndrome  

作　　者：HANG Chen Chen GUO Yu Hong LI Chun Sheng WANG Shuo 

机构地区：[1]Emergency medicine clinical research center of Beijing Chao-Yang Hospital,Capital Medical University,Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation,Beijing 100020,China [2]Medical Affairs Office,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China [3]Department of emergency medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China [4]Department of infectious diseases(Fever clinic),Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China

出　　处：《Biomedical and Environmental Sciences》2021年第12期1029-1032,共4页生物医学与环境科学（英文版）

摘　　要：Acute respiratory distress syndrome(ARDS)is a syndrome characterized by significant lung edema,impaired permeability of lung microvascular endothelial cells with the mal-expression of aquaporins(AQPs).In this study,a two-hit porcine model of ARDS induced by smoking and methicillinresistant Staphylococcus aureus(MRSA)was developed,we investigate the AQPs expression and the influence of Ulinastatin(UTI)to them.Forty-nine healthy male domestic pigs aged 8–10 weeks and weighing 30±2 kg were used for the study.Anesthesia was maintained through continuous intravenous infusion of pentobarbital[8 mg/(kg∙h)].A 5-Fr PiCCO catheter(Pulsiocath PV2015L20;Pulsion Medical Systems,Munich,Germany)and a central venous catheter was inserted for hemodynamic monitoring,including mean arterial pressure(MAP),cardiac index(CI),systemic vascular resistance index(SVRI)and extravascular lung water index(ELWI).

关 键 词：Acute LUNG IMPAIRED 

分 类 号：R563.8[医药卫生—呼吸系统]