介孔材料促进骨修复的优势  

Advantage of mesoporous materials in bone repair

作　　者：高飞飞 杜斌 刘锌 陈浩 陈阳 侯伟 Gao Feifei;Du Bin;Liu Xin;Chen Hao;Chen Yang;Hou Wei(Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu Province,China;Department of Orthopedics and Traumatology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu Province,China)

机构地区：[1]南京中医药大学附属医院,江苏省南京市210029 [2]南京中医药大学附属医院骨伤科,江苏省南京市210029

出　　处：《中国组织工程研究》2022年第21期3401-3409,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(82074471),项目负责人:杜斌,国家自然科学基金青年基金(81804417),项目负责人:刘锌;江苏省卫生健康委科研项目(K2019027),项目负责人:杜斌。

摘　　要：背景:介孔材料具有高比表面积、高孔容、孔径连续可控等特点是优秀的缓释载体材料,其在骨修复领域应用广泛。目的:总结介孔材料在骨修复领域中的应用进展。方法:由第一作者检索1990年1月至2021年4月Pub Med、Web of Science、中国知网及万方数据库中相关文献,英文检索词为"Mesoporous nanoparticles,Biological materials,Control release,Bone regeneration,Mesoporous materials,Support material,Nanomaterials,Porous materials",中文检索词为"生物材料、介孔材料、骨再生、骨修复、药物控释、支架材料、纳米材料、多孔材料"。最终纳入72篇文献进行分析总结。结果与结论:(1)介孔材料治疗骨缺损疾病有着独有的优势:介孔低纳米级的孔径可以有效控制药物(如骨形态发生蛋白、庆大霉素等)长期稳定地释放;一些介孔材料不仅可以被生物体吸收,甚至自身具有骨诱导活性促进骨生成;某些材料不仅机械强度高,而且有更加轻便等优良特性。(2)目前在此方面研究较多的几类材料有硅基材料、碳材料、羟基磷灰石、生物玻璃及金属材料,这些材料结构稳定、易于表面功能化,有着良好的生物相容性且机械性能好,是治疗修复骨缺损的优秀候选材料。(3)在硅基材料中,二氧化硅的中空微球结构使得其载药量大,硅酸盐材料可被生物体吸收或者与骨整合。(4)介孔碳材料有2类,其一是介孔碳微球,中空球体,载药量大,可被生物体代谢;其二介孔碳纳米管,机械强度极高,材料轻便,具有导电性,有一定骨诱导能力,可成为骨替代材料,这使其成为最富有应用前景的骨修复材料,甚至替代缺损肢体成为新型生物义肢。(5)羟基磷灰石具有骨传导能力,在骨修复治疗的临床已得到广泛应用(如牙科修复材料),其介孔化负载骨形态发生蛋白后,植入非承重骨缺损部位时,不仅可促进骨再生而且羟基磷灰石可被生物体吸收。(6)介孔�BACKGROUND:Mesoporous materials are characterized by high specific surface area,high entrance,and continuous aperture control,and good controlreleased carrier materials.Its application in the field of bone repair is various.OBJECTIVE:To summarize the application of mesoporous materials in bone repair.METHODS:The first author searched the relevant articles in PubMed,Web of Science,CNKI,and Wanfang databases from January 1990 to April 2021 with the search terms of“mesoporous nanoparticles,biological materials,control release,bone regeneration,mesoporous materials,support material,nanomaterials,porous materials”in English and“biomaterials,mesoporous materials,bone regeneration,bone repair,drug controlled release,scaffold materials,nanomaterials,porous materials”in Chinese.A total of 72 articles were finally included for analysis and summary.RESULTS AND CONCLUSION:(1)Mesoporous materials have unique advantages for bone defect diseases.The mesoporous low nanometer pore size can effectively control the long-term and stable release of drugs(such as bone morphogenetic protein and gentamicin).Some mesoporous materials can not only be absorbed by organisms,but also have osteoinductive activity to promote bone formation.Some materials not only have high mechanical strength,but also have excellent characteristics such as light weight.(2)At present,the main types of materials that have been studied in this area are:silicon-based materials,carbon materials,hydroxyapatite,bioglass,and metal materials.These materials have stable structure,easy surface functionalization,good biocompatibility,and good mechanical properties,which make these materials become excellent materials for repairing bone defects.(3)In silicon-based materials,the hollow microsphere structure of silicon dioxide makes it carry a large amount of drug,and the silicate materials can be absorbed by organisms or integrated with bones.(4)There are two types of mesoporous carbon materials.One is mesoporous carbon microspheres,which are hollow spheres with a l

关 键 词：介孔材料 生物材料 骨再生 骨修复 药物控释 支架材料 纳米材料 多孔材料 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]