铜离子在骨组织工程中的应用:生物相容性、抗菌性、血管生成活性及成骨活性  

Application of copper ion in bone tissue engineering:biocompatibility,antibacterial properties,angiogenic activity and osteogenic activity

作　　者：郭苏童 郭宇 王凌 李雅欣 丁育健 高静锋 徐海涛 任天皓 冯德宏 Guo Sutong;Guo Yu;Wang Ling;Li Yaxin;Ding Yujian;Gao Jingfeng;Xu Haitao;Ren Tianhao;Feng Dehong(Department of Orthopedics,Affiliated Wuxi People’s Hospital of Nanjing Medical University,Wuxi 214000,Jiangsu Province,China)

机构地区：[1]南京医科大学附属无锡人民医院骨科,江苏省无锡市214000

出　　处：《中国组织工程研究》2022年第21期3410-3414,共5页Chinese Journal of Tissue Engineering Research

基　　金：2019年度无锡市社会发展科技示范(医疗卫生类)项目(N20192006),项目负责人:冯德宏。

摘　　要：背景:铜离子因具有良好的生物相容性、抗菌性、血管生成活性及成骨活性在骨组织工程领域研究和应用正日益深入。目的:总结铜离子在在骨组织工程领域研究和应用及未来的发展方向。方法:检索2000年2月至2021年2月期间PubMed数据库、中国知网、万方数据库收录的文献,中文检索词为"铜,生物相容性,抗菌性,血管生成活性,成骨活性,骨组织工程",英文检索词为"copper,biocompatibility,antibacterial properties,angiogennesis,osteogenic differentiation,bone tissue engineering"。结果与结论:(1)在骨组织领域中,铜离子具有良好的生物相容性、抗菌性、血管生成活性及成骨活性;在细胞水平上,铜离子可促进成骨细胞分化,抑制破骨细胞分化进而影响骨的代谢;在分子生物学水平上,铜离子可通过影响缺氧诱导因子1α通路、ERK1/2信号传导、整联蛋白信号传导、TLR信号传导等从而影响骨的代谢;(2)当前铜离子血管生成机制、成骨机制的研究相对较少;(3)对于铜离子在骨组织工程中应用的研究或可在一定程度上减少假体周围感染、假体松动等情况的发生。BACKGROUND:Due to its good biocompatibility,antibacterial activity,angiogenic activity and osteogenic activity,copper ion has been increasingly studied and applied in the field of bone tissue engineering.OBJECTIVE:To summarize the research and application of copper ion in bone tissue engineering and its future development direction.METHODS:The relevant articles published between February 2000 and February 2021 were retrieved on PubMed,CNKI and Wanfang databases.The English and Chinese search terms were“copper,biocompatibility,antibacterial properties,angiogenesis,osteogenic differentiation,bone tissue engineering”.RESULTS AND CONCLUSION:(1)In the field of bone tissue,copper ion has good biocompatibility,antibacterial activity,angiogenic activity and osteogenic activity.At the cellular level,copper ions can promote the differentiation of osteoblasts,inhibit osteoclast differentiation and affect bone metabolism.At the molecular biology level,copper ions can affect the hypoxia-inducible factor 1αpathway and ERK1/2 signal transduction,Integrin signaling,and TLR signaling,which affect bone metabolism.(2)There are relatively few studies on the mechanism of copper angiogenesis and osteogenesis.(3)The research on the application of copper ions in bone tissue engineering may reduce the occurrence of periprosthesis infection and prosthesis loosening to some extent.

关 键 词：铜离子 生物相容性 抗菌性 血管生成活性 成骨活性 骨组织工程 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]