与骨缺损区域骨组织再生相匹配的新型硅酸钙(基)支架的性能优化  

Performance optimization of a new type of calcium silicate(based)scaffold matched with bone tissue regeneration in the bone defect area

作　　者：张春雨[1] 胡宝阳 冯瑶 张万芬 孙磊叶 阳燕[1,3] Zhang Chunyu;Hu Baoyang;Feng Yao;Zhang Wanfen;Sun Leiye;Yang Yan(Xiangya School of Stomatology,Central South University,Changsha 410000,Hunan Province,China;Xiangya School of Medicine,Central South University,Changsha 410000,Hunan Province,China;Department of Prosthodontics,Xiangya Stomatological Hospital,Central South University,Changsha 410000,Hunan Province,China)

机构地区：[1]中南大学湘雅口腔医学院,湖南省长沙市410000 [2]中南大学湘雅医学院,湖南省长沙市410000 [3]中南大学湘雅口腔医院修复科,湖南省长沙市410000

出　　处：《中国组织工程研究》2022年第21期3421-3428,共8页Chinese Journal of Tissue Engineering Research

基　　金：湖南省大学生创新训练项目项目(S2020105330518),项目负责人:张春雨;中南大学教育教学改革研究项目(2020jy137-2),项目负责人:阳燕。

摘　　要：背景:硅酸钙支架因为具有良好的生物相容性、骨诱导性、骨传导活性及具备一定的生物降解性而备受关注,但由于硅酸钙成骨效应不稳定、降解速率快以及力学性能差的原因,目前尚未应用于临床骨缺损修复中。目的:详细回顾近年来优化硅酸钙支架性能的研究进展,总结单相硅酸钙支架在骨缺损修复应用中的潜力和不足,探索其用于临床骨缺损修复的可能性。方法:通过中国知网、万方、Pub Med、Elsevier及Web of Science数据库,以"3D print,calcium silicate,osteogenesis,composite modification,angiogenesis,stress distribution,bone defect repairing"为英文检索词,"3D打印、硅酸钙、成骨诱导、复合改性、成血管诱导、应力分布、骨缺损修复"为中文检索词,检索近20年的相关文献,通过纳入、排除标准筛选,最终纳入文献共83篇,基于终筛文献对骨组织工程中硅酸钙(基)支架性能优化的研究进展及挑战进行系统全面的分析阐述。结果与结论:(1)硅酸钙材料具有一定的促骨髓间充质干细胞成骨成血管定向分化的潜力,一定的可降解性,游离的Ca2+和Si4+可诱导羟基磷灰石沉积、促进Ⅰ型胶原分泌以及成骨细胞分化,进而增加骨密度,促进矿化环节,目前已成为骨修复领域最有潜力的前沿研究方向。(2)然而单相硅酸钙支架在机械性能、生物活性和降解速率上难以完全适配骨缺损区域的骨组织再生,故尚未在临床上广泛使用。(3)目前,针对硅酸钙(基)支架性能优化的研究虽较丰富,但是缺乏系统的整理归纳,文章将硅酸钙(基)支架的性能优化手段归纳为支架结构的优化和支架材料组成的优化共2大类。(4)硅酸钙(基)支架的结构优化以3D打印技术效果最为突出,3D打印技术通过精确调控支架的孔隙率和孔径大小,可以使硅酸钙(基)支架拥有更优的应力分布模式和成骨成血管效应;(5)硅酸钙支架材料组成的优化是借�BACKGROUND:Calcium silicate scaffolds have atiracted more and more atiention,because of their high biocompatibility,osteoinduction and osteoconduction activities,and a degree of biodegradation.However,due to the unstable osteogenic effect,fast degradation rate and poor mechanical properties of calcium silicate,it has not yet been used in clinical bone defect repair.OBJECTIVE:To review research progress in optimizing the performance of calcium silicate scaffolds,summarize the potential and insufficiency of the singlephase calcium silicate scaffolds applied in bone defect repair,and to explore the possibility of its use in clinical bone defect repair.METHODS:The search was performed on CNKI,Wanfang,PubMed,Elsevier,and Web of Science databases.With the keywords of“3 D print,calcium silicate,osteogenesis,composite modification,angiogenesis,stress distribution,bone defect repairing”in Chinese and English,related articles in recent 20 years were retrieved.According to the inclusion and exclusion criteria,83 papers were finally reviewed.Based on the final screening articles,the research progress and challenges of the performance optimization of calcium silicate based scaffolds in bone tissue engineering were systematically and comprehensively analyzed.RESULTS AND CONCLUSION:(1)Calcium silicate materials have a certain potential to promote osteogenic and angiogenic differentiation of bone marrow mesenchymal stem cells,and have certain degradability.Free Ca2+and Si4+can induce hydroxyapatite deposition,promote collagen-I secretion and differentiation of osteoblasts,thereby increasing bone mineral density and promoting mineralization.Now,it has become one of the most promising frontier research direction in the field of bone repair.(2)However,single-phase calcium silicate scaffolds are not fully suitable for bone tissue regeneration in bone defect area in terms of mechanical properties,biological activity,and degradation rate,so it has not been widely used in clinical practice.(3)At present,there are abundant studies o

关 键 词：硅酸钙 骨缺损修复 3D打印 复合改性 应力分布 成骨诱导 成血管诱导 支架材料 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]