不同骨组织工程支架设计与骨传导性、骨诱导性及生物降解性变化的关系  

Relationship of the design of different bone tissue engineering scaffolds with the changes of osteoconduction,osteoinductivity and biodegradability

作　　者：汪雕雕 孙雨阳 田壮 张矗 李汉臣 姚琦 Wang Diaodiao;Sun Yuyang;Tian Zhuang;Zhang Chu;Li Hanchen;Yao Qi(Ninth Clinical Medical College of Peking University,Beijing 100038,China;Department of Joint Surgery,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038,China;Beijing Institute of Traumatic Orthopedics,Beijing 100035,China)

机构地区：[1]北京大学第九临床医学院,北京市100038 [2]首都医科大学附属北京世纪坛医院关节外科,北京市100038 [3]北京市创伤骨科研究所,北京市100035

出　　处：《中国组织工程研究》2022年第21期3435-3444,共10页Chinese Journal of Tissue Engineering Research

基　　金：首都医科大学附属北京世纪坛医院突发事件紧急医学救援专项基金(2019-JJ03),项目负责人:姚琦;北京市百千万人才项目(2019BQW),项目负责人:姚琦。

摘　　要：背景:骨移植是临床中骨缺损治疗的主要方法,由于自体移植及异体移植的限制,组织工程骨作为替代品变得尤为重要。理想的组织工程骨需具有良好的生物学特性,这取决于支架材料的微观结构及化学性质等因素。目的:骨组织工程支架的不同设计如何影响支架的骨传导性、骨诱导性及生物降解性3种生物学特性。方法:以"骨组织工程、骨传导性、骨诱导性、黏附、扩散、物理特性、化学特性、结构特性、生长因子、离子、生物降解性、聚合物、无机材料、金属"为中文检索词检索中国知网数据库;以"bone tissue engineering,osteoconduction,osteoinductivity,adhesion,diffusion,physical characteristics,chemical characteristics,structural characteristics,growth factors,ions,biological degradability,polymer,inorganic material,metal"为英文检索词检索Pub Med数据库,收集2000年1月至2021年7月时间段与骨组织工程支架生物学特性相关的文献,最终共纳入91篇文章进行综述分析。结果与结论:(1)支架的骨传导性及骨诱导性的影响因素主要包括物理因素,如支架刚度及表面亲水性、生化因素、表面生化结构、结构因素、孔隙结构和表面形貌,此外,影响骨诱导性的因素还包括诱导分化物质的递送等。(2)对于骨传导性及骨诱导性的设计,可通过改善上述多种因素,进而通过促进蛋白的黏附、调节细胞-支架间的相互作用等机制促进骨再生过程。(3)支架的生物降解性主要与材料性质有关,聚合物、无机材料和金属等不同种类的材料具有不同降解特性和机械性能。(4)骨组织工程支架设计时,可通过结合不同性质的材料,以促进支架的降解性,同时平衡材料的降解性与机械性能间的关系。BACKGROUND:Bone gratis are the main method for the treatment of bone defects in clinic.Due to the limitation of autogratis and allogratis,bone tissue-engineered materials have become particularly important as a substitute.The ideal bone tissue-engineered materials must have good biological characteristics,which depend on the microstructure and chemical properties of the scaffold material.OBJECTIVE:How do different designs of bone tissue engineering scaffolds affect the biological characteristics of bone conductivity,osteoinductivity,and biological degradability of scaffolds.METHODS:Keywords were “bone tissue engineering,osteoconduction,osteoinductivity,adhesion,diffusion,physical characteristics,chemical characteristics,structural characteristics,growth factors,ions,biological degradability,polymer,inorganic material,metal” in Chinese and English.CNKI and Pub Med databases were searched for articles regarding biological characteristics of bone tissue engineering scaffolds published from January 2000 to July 2021.Finally,91 articles were included for review.RESULTS AND CONCLUSION:(1) In the design of bone tissue engineering scaffolds,factors affecting osteoinductivity and osteoconduction contain material stiffness,wetiability,biochemical factors,surface biochemical structure,structural agent,pore structure,and surface morphology.In addition,the factors affecting bone inducibility also include the delivery of differentiation inducing substances.(2) The design of bone conduction and bone induction can improve the above factors,and then promote bone regeneration by promoting the adhesion of proteins and regulating the cell-scaffold interaction.(3) The biodegradability of scaffolds is mainly related to material properties,and different kinds of materials such as polymers,inorganic materials and metals have different degradation characteristics and mechanical properties.(4) In the design of scaffolds,materials with different properties can be combined to promote the degradation of scaffolds and balance the relation

关 键 词：骨 材料 骨组织工程 支架设计 骨传导性 骨诱导性 生物降解性 机械性能 

分 类 号：R459.9[医药卫生—治疗学] R363[医药卫生—临床医学]