清热利湿颗粒治疗湿热体质型高尿酸血症临床观察  

Clinical observation of Qingre Lishi granule in the treatment of hyperuricemia of damp-heat constitution type

作　　者：许艺娴 李雅茜[1] 黄小敏 胡冬梅 周晓燕[1] XU Yi-xian;LI Ya-qian;HUANG Xiao-min;HU Dong-mei;ZHOU Xiao-yan(The Second Department of Internal Medicine,Guangzhou Tianhe District Hospital of Traditional Chinese Medicine,Guangzhou 510655,Guangdong,CHINA)

机构地区：[1]广州市天河区中医医院内二科,广东广州510655

出　　处：《海南医学》2022年第2期172-174,共3页Hainan Medical Journal

基　　金：广东省中医药局科研课题资助项目(编号:20202140);广东省广州市中医药和中西医结合科技项目(编号:20202A011029);广东省基层老中医药专家传承工作室建设项目(编号:穗卫函[2020]6号);广东省广州市基层名中医传承工作室建设项目(编号:穗卫中医[2019]1号)。

摘　　要：目的观察清热利湿颗粒治疗湿热体质型高尿酸血症患者的临床疗效。方法选取2020年1月至2021年4月天河区中医医院收治的70例湿热体质型高尿酸血症患者,按照随机数表法分为观察组与对照组,每组35例,观察组患者给予清热利湿颗粒口服治疗,对照组患者给予碳酸氢钠片口服治疗,疗程均为4周。比较两组患者治疗前后的血清尿酸水平、中医体质转化分和肝肾功能等指标的变化,评价两组患者的临床疗效及安全性。结果治疗4周后,观察组患者的总有效率为94.29%,明显高于对照组的71.43%,差异有统计学意义(P<0.05);治疗后,观察组患者的血尿酸水平为(370.71±62.58)μmol/L,明显低于对照组的(436.17±64.92)μmol/L,差异有统计学意义(P<0.05);治疗后,观察组患者的中医体质转化分为(39.91±5.14)分,明显低于对照组的(49.23±7.03)分,差异有统计学意义(P<0.05);治疗过程中,两组患者均无明显不良反应发生,且肝肾功能无明显异常。结论清热利湿颗粒治疗湿热体质型高尿酸血症患者疗效确切,不良反应少,安全有效。Objective To observe the clinical effect of Qingre Lishi Granule in the treatment of hyperuricemia patients of damp-heat constitution type. Methods A total of 70 patients with hyperuricemia of damp-heat constitution type treated in Guangzhou Tianhe District Hospital of Traditional Chinese Medicine from January 2020 to April 2021 were selected. They were randomly divided into observation group and control group, with 35 patients in each group.The observation group received oral treatment with Qingre Lishi Granules, and the control group received oral treatment with sodium bicarbonate tablets. Both groups were treated for 4 weeks. The changes of serum uric acid level, TCM constitution transformation score, and liver and kidney function were compared between the two groups before and after treatment, and the clinical efficacy and safety of the two groups were evaluated. Results After 4 weeks of treatment,the total effective rate of the observation group was 94.29%, which was significantly higher than 71.43% of the control group(P<0.05). After treatment, the blood uric acid level in the observation group was(370.71±62.58) μmol/L, which was significantly lower than(436.17±64.92) μmol/L in the control group(P<0.05). After treatment, the TCM physical transformation of the patients in the observation group was(39.91 ± 5.14) points, which was significantly lower than(49.23±7.03) points in the control group(P<0.05). During the treatment, there were no obvious adverse reactions in both groups, with no obvious abnormalities in liver and kidney function. Conclusion Qingre Lishi Granules has a definite effect in treating damp-heat constitutional hyperuricemia, with few adverse reactions, safe and effective.

关 键 词：高尿酸血症 湿热体质型 清热利湿颗粒 疗效 安全性 

分 类 号：R696[医药卫生—泌尿科学]