吸烟对冠状动脉慢性完全闭塞病变患者的影响  

Impact of Smoking on Patients with Chronic Coronary Artery Occlusion

作　　者：王娟[1] 许浩博 乔树宾[1] 管常东 胡奉环[1] 杨伟宪[1] 袁建松[1] 崔锦刚[1] 宋雷[1] 郭超[1] 徐波[1] WANG Juan;XU Hao-bo;QIAO Shu-bin;GUAN Chang-dong;HU Feng-huan;YANG Wei-xian;YUAN Jian-song;CUI Jin-gang;SONG Lei;GUO Chao;XU Bo(Center for Coronary Heart Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院,北京协和医学院国家心血管病中心,阜外医院冠心病中心,北京市100037

出　　处：《中国分子心脏病学杂志》2021年第6期4292-4295,共4页Molecular Cardiology of China

摘　　要：目的研究吸烟对慢性完全闭塞病变(CTO)的冠状动脉粥样硬化性心脏病患者临床特点的影响。方法回顾性分析阜外医院住院期间接受经皮冠脉介入(PCI)治疗的冠状动脉CTO患者,收集其临床资料、实验室检查、冠脉造影及介入操作资料,分析吸烟对其临床特点的影响。结果共纳入2659例2010年1月至2013年10月于阜外医院接受PCI治疗的CTO患者,结果显示,吸烟组冠心病患者较非吸烟组年龄更轻[(55.91±9.95)岁比(58.15±10.79)岁,P<0.0001],同时合并外周动脉疾病比例增加(7.07%比2.49%,P<0.0001)。吸烟组患者冠脉CTO闭塞段长度更长[(18.17±12.74)mm比(16.99±11.75)mm,P=0.002],且吸烟组患者中冠脉钙化比例明显增高(15.00%比11.84%,P=0.02)。倾向值匹配分析后,吸烟组患者中冠脉病变钙化比例仍明显增高(15.35%比10.68%,P=0.002),合并外周动脉疾病比例明显高于非吸烟组(6.99%比2.13%,P<0.0001)。结论吸烟的冠脉CTO患者年龄更轻,冠脉CTO闭塞段更长,冠脉钙化比例增高,外周动脉床受累更常见。Objective To investigate the impact of smoking on the characteristics of patients diagnosed with chronic total occlusion(CTO).Methods The patients with coronary CTO who received percutaneous coronary intervention(PCI)in Fuwai Hospital were analyzed retrospectively.The clinical data,laboratory examination,coronary angiography and interventional operation data were collected,and the influence of smoking on their clinical characteristics was analyzed.Results A total of 2659 cases of patients with CTO and received PCI in Fuwai Hospital from January 2010 to October 2013 were enrolled in the study.Compared with non-smoking group,patients in smoking group were significantly younger(55.91±9.95 vs.58.15±10.79,P<0.0001),the proportion of peripheral vascular diseases increased(7.07%vs.2.49%,P<0.0001),the length of the lesion was longer(18.17±12.74 vs.16.99±11.75,P=0.002)and the proportion of calcification(15.00%vs.11.84%,P=0.02)were significantly higher in the smoking group.Propensity match analysis results showed that the proportion of calcification in the smoking group was still significantly higher(15.35%vs.10.68%,P=0.002),and the history of peripheral vascular disease in the smoking group was significantly higher(6.99%vs.2.13%,P<0.0001).Conclusion Smoking patients with coronary CTO are younger,the occluded segment of coronary CTO is longer,the proportion of coronary calcification is higher,and the involvement of peripheral arterial bed is more common.

关 键 词：慢性完全闭塞病变 吸烟 经皮冠脉介入治疗 外周动脉疾病 冠脉钙化 

分 类 号：R543.3[医药卫生—心血管疾病]