牛蒡子中牛蒡苷元纳米载药体系的研究  

Nano Drug Delivery System of Arctigenin in Fructus arctii

作　　者：刘斯文 史锐 刘苗苗 丛龙娇 黄晓彤 LIU Siwen;SHI Rui;LIU Miaomiao;CONG Longjiao;HUANG Xiaotong(College of Pharmacy,Liaoning University of Traditional Chinese Medicine,Dalian 110000,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连110000

出　　处：《化学与生物工程》2022年第1期40-44,共5页Chemistry & Bioengineering

基　　金：辽宁中医药大学中医脏象理论及应用教育部重点实验室开放基金项目(zyzx2001)。

摘　　要：对介孔二氧化硅纳米颗粒(MSN)进行叶酸(FA)和氧化锌(ZnO)双重修饰,制备了装载牛蒡苷元(ARG)的纳米载药体系FA@ZnO-MSN-ARG,采用扫描电子显微镜(SEM)、透射电子显微镜(TEM)、X-射线衍射仪(XRD)和N_(2)吸附-脱附分析等方法对纳米载药体系FA@ZnO-MSN-ARG进行表征,并对其载药性能和释药性能进行了评价。结果表明,随着牛蒡苷元与载体比例的增加,载药体系MSN-ARG和FA-MSN-ARG的载药率升高、包封率降低,载药体系FA@ZnO-MSN-ARG的载药率和包封率远高于MSN-ARG、FA-MSN-ARG;在载药体系FA@ZnO-MSN-ARG中加入谷胱甘肽(GSH),释药率明显升高,在36 h时达到最高,为39.25%。该载药体系具有缓释、控释效果,为牛蒡子的进一步开发利用提供了理论依据。We modified mesoporous silica nanoparticles(MSN)by folic acid(FA)and zinc oxide(ZnO),and prepared the nano drug delivery system FA@ZnO-MSN-ARG loaded with arctigenin(ARG).Moreover,we characterized the nano drug delivery system FA@ZnO-MSN-ARG by SEM,TEM,XRD,and N_(2) adsorption-desorption analysis,and evaluated its drug loading and release properties.The results show that,with the increase of the ratio of ARG to carrier,the drug loading ratios of the drug delivery systems MSN-ARG and FA-MSN-ARG increase,while the encapsulation efficiencies decrease.The drug loading ratio and encapsulation efficiency of FA@ZnO-MSN-ARG are much higher than those of MSN-ARG and FA-MSN-ARG.When glutathione(GSH)is added into the drug delivery system FA@ZnO-MSN-ARG,the drug release rate significantly increases and reaches the highest of 39.25%at 36 h.The drug delivery system has sustained and controlled release effects,which provides a theoretical basis for the further development and utilization of Fructus arctii.

关 键 词：牛蒡子 牛蒡苷元 谷胱甘肽 纳米载药体系 

分 类 号：R944.9[医药卫生—药剂学]