单核细胞/高密度脂蛋白胆固醇与高尿酸血症患病率的关联及性别差异研究  

Overall and Sex-specific Associations between Ratio of Monocyte to High-density Lipoprotein Cholesterol and Hyperuricemia Prevalence

作　　者：王燕萍 邬美花 杨胜 陈忠[2] WANG Yanping;WU Meihua;YANG Sheng;CHEN Zhong(Department of General Practice,Shanghai Pudong New Area Laogang Community Health Center,Shanghai 201302,China;Cardiovascular Department,the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海市浦东新区老港社区卫生服务中心全科,201302 [2]上海交通大学附属第六人民医院心内科,上海市200233

出　　处：《中国全科医学》2022年第6期714-718,723,共6页Chinese General Practice

基　　金：上海申康医院发展中心科研项目(SHDC12017X24);上海市浦东新区科经委科研项目(PKJ2018-Y53)。

摘　　要：背景高尿酸血症(HUA)是一种常见的代谢性疾病,可对全身多个靶器官造成损害。研究证实HUA与炎性标志物密切相关,单核细胞/高密度脂蛋白胆固醇(MHR)作为一种新型炎性标志物在社区易获得,研究MHR与HUA间的关联对社区HUA防治工作有重要意义。目的研究MHR与HUA的关联,探讨MHR作为一种新型炎性标志物的价值及性别差异。方法收集参加2020年上海市浦东新区老港镇50岁以上中老年人体检的人群的一般资料及检验数据,计算MHR。共纳入体检信息完整的中老年人12305例,其中男5498例(44.7%),女6807例(55.3%)。HUA定义为女性血尿酸(SUA)>360μmol/L,男性SUA>420μmol/L。采用多因素Logistic回归分析探究HUA与MHR的关系,并按性别分层。结果本研究中老年人HUA总患病率为15.8%(1948/12305),男性为17.7%(974/5498),女性为14.3%(974/6807)。多因素Logistic回归分析结果显示,单核细胞(MONO)〔男性:OR=2.010,95%CI(1.265,3.194);女性:OR=5.427,95%CI(3.059,9.627)〕、MHR〔男性:OR=1.918,95%CI(1.111,3.313);女性:OR=6.073,95%CI(2.984,12.358)〕是男性和女性发生HUA的独立影响因素(P<0.05)。结论男性和女性MHR与HUA的发生风险均呈独立相关,与男性相比,MHR与HUA患病率的相关性在女性中更显著。Background Hyperuricemia(HUA)is a common metabolic disease,which may cause damage to multiple target organs.Studies have showed that HUA is strongly related to inflammatory markers.It is of great importance to study the relationship of HUA with monocyte to high-density lipoprotein cholesterol ratio(MHR),a new inflammatory marker that could be obtained easily in the community,for community-based prevention and treatment of HUA.Objective To examine the overall and sex-specific associations between MHR and HUA,to assess the predictive value of HUA for HUA.Methods The demographic and 2020 physical examination data of 12305 subjects over 50 years old〔5498 men(44.7%)and 6807 women(55.3%)〕from Laogang community of Shanghai's Pudong New Area were analyzed retrospectively.HUA was defined as serum uric acid level>360µmol/L in women,and>420µmol/L in men.Multivariate Logistic regression was used to examine the association between MHR and HUA in all participants,and in men and women,respectively.Results The prevalence of HUA in all participants,men and women was 15.8%(1948/12305),17.7%(974/5498),and 14.3%(974/6807),respectively.After adjusting for confounding factors,monocyte〔male,OR=2.010,95%CI(1.265,3.194);female,OR=5.427,95%CI(3.059,9.627)〕and MHR〔male,OR=1.918,95%CI(1.111,3.313);female,OR=6.073,95%CI(2.984,12.358)〕were independently associated with HUA in both men and women(P<0.05).Conclusion MHR was independently associated with HUA in men and women,and the association was stronger in women.

关 键 词：高尿酸血症 单核细胞与高密度脂蛋白比值 患病率 危险因素 性别因素 

分 类 号：R589.9[医药卫生—内分泌]