桥接整合因子1与心血管疾病的关系研究  

Research of the Relationship Between Bridging Integrator 1 and Cardiovascular Diseases

作　　者：王小忠 常先松 赵良平[2] 张代民[3] WANG Xiao-zhong;CHANG Xian-song;ZHAO Liang-ping;ZHANG Dai-min(Department of Emergency,the Second Hospital Affiliated to Soochow University Xuguan District,Suzhou 215151,Jiangsu,China;Department of Cardiology,the Second Affiliated Hospital of Soochow University,Suzhou 215004,Jiangsu,China;Department of Cardiology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210001,Jiangsu,China)

机构地区：[1]苏州大学附属第二医院浒关院区急诊科,江苏苏州215151 [2]苏州大学附属第二医院心内科,江苏苏州215004 [3]南京医科大学附属南京医院心内科,江苏南京210001

出　　处：《医学信息》2022年第1期46-49,共4页Journal of Medical Information

基　　金：苏州工业园区心馨心血管健康基金会项目(编号:2019-CCA-ACCESS-058);江苏省自然科学基金项目(编号:BK20151085)。

摘　　要：桥接整合因子1(Bin1)是双联蛋白家族的成员之一,能有效调节细胞内吞、细胞膜循环、细胞骨架形成、DNA修复、细胞周期进展和凋亡等细胞功能。Bin1是心肌细胞横管系统的重要组成部分,参与心肌细胞的兴奋-收缩耦联反应。Bin1是一种潜在的心力衰竭生物标志物,其表达降低与心力衰竭的发生和严重程度相关。Bin1表达缺失的心肌细胞的膜电位稳定性差,易发生心律失常。在心肌梗死中,梗死心肌组织的Bin1表达减少或缺失,影响心肌的收缩功能。给予外源性Bin1,或采用合适的药物增加Bin1的表达,可能在心血管疾病防治中发挥一定作用。本文就Bin1的结构特点和细胞功能,Bin1与心肌梗死、心律失常和心力衰竭的关系进行综述,以期为临床治疗心血管疾病提供帮助。Bridging integrator 1(Bin1)is one of the members of the amphiphy family,which can regulate cell functions such as endocytosis,membrane circulation,cytoskeleton formation,DNA repair,cell cycle progression and apoptosis.Bin1 is an important part of the transverse tube system of cardiomyocytes,and participates in the excitation contraction coupling reaction of cardiomyocytes.Bin1 is a potential biomarker of heart failure,the decreased expression of Bin1 is related to the occurrence and severity of heart failure.The membrane potential of Bin1 deficient cardiomyocytes is unstable and prone to arrhythmia.In myocardial infarction,the expression of Bin1 in infarcted myocardium is decreased or absent,which affects the contractile function of myocardium.It may play an important role in the prevention and treatment of cardiovascular diseases by giving exogenous Bin1 or increasing the expression of Bin1 with appropriate medicine.This article reviews the structural characteristics and cellular function of Bin1,and the relationship between Bin1 and myocardial infarction,arrhythmia and heart failure,in order to provide help for clinical treatment of cardiovascular diseases.

关 键 词：桥接整合因子1 心力衰竭 心律失常 心肌梗死 

分 类 号：R54[医药卫生—心血管疾病]