The BZR1-EDS1 module regulates plant growth-defense coordination  

作　　者：Guang Qi Huan Chen Dian Wang Hongyuan Zheng Xianfeng Tang Zhengzheng Guo Jiayu Cheng Jian Chen Yiping Wang Ming-yi Bai Fengquan Liu Daowen Wang Zheng Qing Fu 

机构地区：[1]State Key Laboratory of Wheat and Maize Crop Science,College of Agronomy,and Center for Crop Genome Engineering,Henan Agricultural University,Zhengzhou 450002,China [2]Department of Biological Sciences,University of South Carolina,Columbia,SC 29208,USA [3]Institute of Plant Protection,Jiangsu Academy of Agricultural Sciences,Nanjing,210014,China [4]College of Agronomy,Qingdao Agricultural University,Qingdao 266109,China [5]Qingdao Institute of BioEnergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266109,China [6]Key Laboratory of Plant Development and Environment Adaptation Biology,Ministry of Education,School of Life Sciences,Shandong University,266237 Qingdao,China

出　　处：《Molecular Plant》2021年第12期2072-2087,共16页分子植物（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(91935304);the Innovative Postdoctoral Research Initiative of Henan Province(to G.Q.);the National Science Foundation(EAGER grant 1464527 and grant IOS-1758994 to Z.Q.F.).

摘　　要：Plants have developed sophisticated strategies to coordinate growth and immunity,but our understanding of the underlying mechanism remains limited.In this study,we identified a novel molecular module that reg-ulates plant growth and defense in both compatible and incompatible infections.This module consisted of BZR1,a key transcription factor in brassinosteroid(BR)signaling,and EDS1,an essential positive regulator of plant innate immunity.We found that EDS1 interacts with BZR1 and suppresses its transcriptional activ-ities.Consistently,upregulation of EDS1 function by a virulent Pseudomonas syringae strain or salicylic acid treatment inhibited BZR1-regulated expression of BR-responsive genes and BR-promoted growth.Furthermore,we showed that the cytoplasmic fraction of BZR1 positively regulates effector-triggered im-munity(ETI)controlled by the TIR-NB-LRR protein RPS4,which is attenuated by BZR1's nuclear transloca-tion.Mechanistically,cytoplasmic BZR1 facilitated AvrRps4-triggered dissociation of EDS1 and RPS4 by binding to EDS1,thus leading to efficient activation of RPS4-controlled ETI.Notably,transgenic expression of a mutant BZR1 that accumulates exclusively in the cytoplasm improved pathogen resistance without compromising plant growth.Collectively,these results shed new light on plant growth-defense coordina-tion and reveal a previously unknown function for the cytoplasmic fraction of BZR1.The BZR1-EDS1 mod-ule may be harnessed for the simultaneous improvement of crop productivity and pathogen resistance.

关 键 词：BRASSINOSTEROID BZR1 salicylic acid EDS1 basal resistance effector-triggered immunity TIR-NB-LRR resistance protein RPS4 

分 类 号：Q94[生物学—植物学]