不同剂量丙种球蛋白联合阿司匹林治疗小儿川崎病效果观察  

Clinical Efficacy of Different Doses of Gamma Globulin Combined with Aspirin in Treatment of Children with Kawasaki Disease

作　　者：徐玮玮[1] 徐利[1] 杨蕾 XU Wei-wei;XU Li;YANG Lei(Department of Pediatrics,the Affiliated Hospital of Jining Medical College,Jining,Shandong 272000,China)

机构地区：[1]济宁医学院附属医院儿科,山东济宁272000

出　　处：《解放军医药杂志》2022年第1期40-43,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：国家自然科学基金委员会青年科学基金项目(81700702)。

摘　　要：目的观察不同剂量丙种球蛋白联合阿司匹林治疗小儿川崎病的临床效果。方法选取2019年3月—2020年12月本院收治的102例川崎病患儿,根据丙种球蛋白治疗剂量的不同分为研究组53例(大剂量丙种球蛋白2 g/kg联合阿司匹林治疗)和对照组49例(小剂量丙种球蛋白400 mg/kg联合阿司匹林治疗)。比较2组临床症状改善情况(退热时间、颈淋巴结增大消退时间、手足肿胀消退时间、黏膜充血消退时间),临床疗效、实验室指标[C反应蛋白(CRP)、白细胞计数(WBC)、红细胞沉降率(ESR)、血小板计数(PLT)]及不良反应。结果研究组退热时间、颈淋巴结增大消退时间、手足肿胀消退时间、黏膜充血消退时间均短于对照组(P<0.01);研究组临床总有效率高于对照组(P<0.05);治疗后2组WBC、CRP、ESR、PLT均下降,其中研究组下降程度更为显著(P<0.05,P<0.01);2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论大剂量丙种球蛋白联合阿司匹林治疗小儿川崎病,可有效提高疗效,减轻患儿炎症反应,安全性较佳。Objective To observe clinical efficacy of different doses of Gamma Globulin combined with Aspirin in treatment of children with Kawasaki disease.Methods A total of 102 children with Kawasaki disease admitted between March 2019 and December 2020 were selected and divided into research group(high-dose Gamma Globulin 2 g/kg combined with Aspirin,n=53)and control group(low-dose Gamma Globulin 400 mg/kg combined with Aspirin,n=49)according to different doses of Gamma Globulin.Improvement conditions of clinical symptoms(antipyretic time,and regression times of cervical lymph node enlargement,hand and foot swelling and mucosal congestion),clinical efficacy,laboratory indexes[C-reactive protein(CRP),white blood cell(WBC)count,erythrocyte sedimentation rate(ESR),platelet count(PLT)]and incidence rate of adverse reactions were compared between two groups.Results The antipyretic time,and regression times of cervical lymph node enlargement,hand and foot swelling,and mucosal congestion in research group were significantly shorter than those in control group(P<0.01).The total effective rate in research group was significantly higher than that in control group(P<0.05).After treatment,levels of WBC,CRP,ESR and PLT were significantly decreased in two groups,and the decreased degrees in research group were more(P<0.05,P<0.01).There was no significant difference in the total incidence rate of adverse reactions between two groups(P>0.05).Conclusion The application of high-dose Gamma Globulin combined with Aspirin in treatment of children with Kawasaki disease may effectively improve curative efficacy and reduce inflammatory reaction with better safety.

关 键 词：黏膜皮肤淋巴结综合征 丙种球蛋白 阿司匹林 临床症状 C反应蛋白 药物毒性 

分 类 号：R543[医药卫生—心血管疾病]