无过渡金属条件下可见光诱导α-重氮酯的氧化合成α-酮酯  

Visible Light Induced Oxidation of α-Diazo Esters for the Transition Metal-Free Synthesis of α-Keto Esters

作　　者：赵保丽 杨良凤[2] 程凯 周丽云[1] 万结平[1] Baoli Zhao;Liangfeng Yang;Kai Cheng;Liyun Zhou;Jie-Ping Wan(College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang 330022;Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process,Shaoxing University,Shaoxing,Zhejiang 312000)

机构地区：[1]江西师范大学化学化工学院,南昌330022 [2]绍兴文理学院浙江省精细化工与传统工艺绿色替代技术重点实验室,浙江绍兴312000

出　　处：《有机化学》2021年第12期4732-4737,共6页Chinese Journal of Organic Chemistry

基　　金：江西省自然科学基金(20202ACBL203006);浙江省教育厅科研计划(Y202147050)。

摘　　要：发展了一例空气氛围下氧气作为无污染氧化剂合成α-酮酯的方法.以易得的α-重氮酯为起始原料,该转化在采用曙红Y作为光敏剂的光诱导条件下进行.反应在室温和空气氛围下操作,底物兼容性好.提供了一个绿色、简便合成结构多样的α-酮酯的方法.Herein, an aerobic oxidation approach for the synthesis of α-keto esters using oxygen as a cheap and pollution-free oxidant has been developed. By using readily available α-diazo esters as starting materials, the transformation was achieved by the inducement of visible light with eosin Y as the light sensitizer. The reactions proceed at room temperature under air atmosphere, tolerating substrates with broad scope, thus providing a green and facile synthetic approach to structurally diverse α-keto esters.

关 键 词：光催化 无过渡金属 空气氧化 α-重氮酯 α-酮酯 

分 类 号：O623.624[理学—有机化学]