高血压脑出血术后应用依达拉奉佑崁醇对患者细胞炎症因子及神经功能的影响  

EFFECTOF TREATMENT OF HYPERTENSIVE INTRACEREBEAL HEMORRHAGE WITH EDARAVONEOL ON CYTOINFLAMMATORY FACTORS AND NEUROLOGICAL FUNCTION IN PATIENTS

作　　者：董伟[1] 张利[1] 王彦[1] 石文建[1] 张欢[1] 董晓柳[2] 高健 张于[3] DONG Wei;ZHANG Li;WANG Yan;SHI Wenjian;ZHANG Huan;DONG Xiaoliu;GAO Jian;ZHANG Yu(Department of Neurosurgery,Tangshan People’s Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山市人民医院神经外科,063000 [2]河北省唐山市人民医院神经康复科 [3]河北省唐山市人民医院ICU

出　　处：《中国煤炭工业医学杂志》2021年第6期618-623,共6页Chinese Journal of Coal Industry Medicine

基　　金：河北省2021年度医学科学研究课题计划项目(编号:20211512);2020年唐山市科学技术研究与发展计划项目(编号:20150205C)。

摘　　要：目的探讨3D-slicer辅助内镜治疗高血压脑出血术后应用依达拉奉佑崁醇对患者细胞炎症因子及神经功能的影响。方法选取2020年8月—2021年8月唐山市人民医院神经外科收治的98例经3D-slicer辅助内镜治疗高血压基底节区脑出血术后的患者作为观察对象,应用计算机随机数字法分为观察组50例和对照组48例,采用前瞻性队列研究方法进行研究。观察组应用依达拉奉右崁醇注射液15 ml+0.9%氯化钠100 ml,2次/d静脉滴注;对照组应用依达拉奉注射液15 ml+0.9%氯化钠100 ml,2次/d静脉滴注。二组疗程均为3周。观察二组细胞炎症因子的改变,应用美国国立卫生研究院卒中量表(NIHSS)评分、巴塞尔指数(Barthel)评分、格拉斯哥昏迷指数(GCS)、格拉斯哥预后评分(GOS)进行比较。结果用药后二组细胞炎症因子均较用药前降低,且观察组肿瘤坏死因子[TNF-α,(37.50±9.18)ng/L]、白细胞介素-6[IL-6,(46.80±9.33)ng/L]、白细胞介素-1β[IL-1β,(11.76±3.06)ng/L]下降幅度大于对照组[(43.19±10.96)ng/L、(53.35±8.39)ng/L、(13.03±3.14)ng/L],二组比较差异有统计学意义(t值分别为2.76、3.62、2.00,均P<0.05)。用药后,观察组NIHSS评分[(11.24±2.24)分]明显低于对照组评分[(12.69±2.97)分],Barthel评分[(59.40±9.48)分]、GCS评分[(12.89±1.01)分]及GOS评分[(3.84±0.86)分]则明显高于对照组评分[(52.83±8.50)分、(12.26±1.19)分、(3.42±0.79)分],四种评分在二组中的改变差异均有统计学意义(t值分别为2.70、3.57、2.25、2.52,均P<0.05)。结论依达拉奉佑崁醇可显著降低3D-slicer辅助内镜高血压脑出血术后患者细胞炎症因子的表达,促进患者神经功能恢复,提高生存质量,提高临床疗效。Objective 3 D-slicer assisted endoscopic treatment of hypertensive intracerebral hemorrhage after the application of edaravoneol can affect the cytoinflammatory factors and neurological function of patients.Methods From August 2020 to August 2021,ninety-eight patients who were admitted to the Department of Neurosurgery of Tangshan People′s Hospital who were treated with 3 D-slicer-assisted endoscopic treatment of hypertensive basal ganglia cerebral hemorrhage were selected as observation objects, and they were divided into random numbers by computer Observation group of 50 cases and control group of 48 cases, were studied by prospective cohort research method.Observation group received edaravone injection 15 ml + 0.9% sodium chloride 100 ml, intravenous drip twice daily;control group received edaravone injection 15 ml + 0.9% sodium chloride 100 ml, 2 times/d intravenous drip.The course of treatment for both groups was 3 weeks.The changes of the two groups of cytoinflammatory factors were observed and compared with the National Institutes of Health Stroke Scale(NIHSS) score, Basel Index(Barthel) score, Glasgow Coma Index(GCS),andGlasgow Outcome Score(GOS).Results After treatment, the levels of tumor necrosis factor[TNF-α,(37.50±9.18)ng/L],interleukin-6[IL-6,(46.80±9.33)ng/L],and interleukin-1β[IL-1β,(11.76±3.06)ng/L]in the two groups were lower than before treatment, and the observation group was lower than the control group[(43.19±10.96)ng/L、(53.35±8.39)ng/L、(13.03±3.14)ng/L].There were differences statistically significant(t=2.76、3.62、2.00,P<0.05).After medication, NIHSS score[(11.24±2.24)score]of the observation group was significantly lower than that of the control group[(12.69±2.97)score],while Barthel score[(59.40±9.48)score],GCS score[(11.14±2.12)score]and GOS score[(3.84±0.86)score]of the observation group were significantly higher than that of the control group[(52.83±8.50)score、(10.21±1.93)score、(3.42±0.79)score],with statistical significance in the changes of the three sco

关 键 词：高血压脑出血 3D-slicer 依达拉奉佑崁醇 细胞炎症因子 神经功能 

分 类 号：R544[医药卫生—心血管疾病]