血管内皮钙黏蛋白与ABO新生儿溶血病患儿血管内皮损伤的相关性研究  

Study on the Relationship between Vascular Endothelial Cadherin and Vascular Endothelial Injury in ABO Hemolytic Disease of Newborn

作　　者：刘鹏 丁建娥 姜丹丹 丁金钰 邵淑玲[1] 董秀梅[1] LIU Peng;DING Jian-e;JIANG Dan-dan(Huangdao District People's Hospital,Qingdao 266400)

机构地区：[1]青岛市黄岛区人民医院,266400

出　　处：《临床输血与检验》2022年第1期80-83,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的探究血管内皮钙黏蛋白(VE-Cad)能否预测ABO新生儿溶血病患儿血管内皮损伤及其与溶血的发生和严重程度的关系。方法选取2020年4月~2020年11月我院收集的50例ABO新生儿溶血病患儿(ABO新生儿溶血病组)、47例母婴血型匹配的健康新生儿(对照组),观察收集两组新生儿同期血红蛋白(Hb)、网织红细胞比率(Ret%)、间接胆红素(IBIL)、乳酸脱氢酶(LDH)的检测数据,并定量检测VE-Cad浓度。结果两组新生儿出生体重、胎龄及检测日龄比较差异无统计学意义(P>0.05),两组新生儿Hb、Ret、IBIL、LDH及VE-Cad水平比较差异有统计学意义(P<0.05),且VE-Cad水平与Ret%、IBIL、LDH水平呈正相关,而与Hb水平呈负相关(P<0.05)。经多重线性回归分析发现:ABO新生儿溶血病组VE-Cad水平与Hb、Ret%、IBIL、LDH水平呈现独立相关性(P<0.05)。结论VE-Cad在ABO新生儿溶血病患儿中的水平升高可用于反映患儿的内皮损伤,并有助于评估可能发生的血管功能障碍风险。Objective To investigate whether vascular endothelial cadherin can predict vascular endothelial injury and its relationship with the occurrence and severity of hemolysis in ABO hemolytic disease of newborn.Methods 50 cases of ABO hemolytic disease of newborn(ABO-HDN Group)and 47 healthy newborns with matching maternal and infant blood types(Control Group)were selected in our hospital from April 2020 to November 2020.The hemoglobin(Hb),reticulocyte percentage(Ret%),indirect bilirubin(IBIL)and lactate dehydrogenase(LDH)were measured at the same time,and the concentration of vascular endothelial cadherin(VE-Cad)was quantitatively measured.Results There was no significant difference in birth weight,gestational age and the age by day on detection between the two groups(P>0.05),but there was significant difference in Hb,Ret%,IBIL,LDH and VE-Cad between the two groups(P<0.05),the VE-Cad level was positively correlated with Ret%,IBIL and LDH,but negatively correlated with Hb(P<0.05).Multiple regression analysis showed that VE-Cad level was independently correlated with Hb,Ret%,IBIL and LDH(P<0.05).Conclusion The increased level of VE-Cad in ABO hemolytic disease of newborn can be used to reflect the endothelial injury of children and help to assess the risk of severe vascular dysfunction.

关 键 词：ABO新生儿溶血病 血管内皮钙黏蛋白 血管内皮损伤 

分 类 号：R446[医药卫生—诊断学]