健康成人左心室重构与血脂比值的独立相关性  

Independent correlation of left ventricular remodeling and lipid ratios in healthy adults

作　　者：谢佳楠 张振 周珊珊 高艺源 李更晓 赵之伟 赵军 骆美辰 娄明武 李坤成[1,5,6] XIE Jianan;ZHANG Zhen;ZHOU Shanshan;GAO Yiyuan;LI Gengxiao;ZHAO Zhiwei;ZHAO Jun;LUO Meichen;LOU Mingwu;LI Kuncheng(Shenzhen Clinical Medical College,Guangzhou University of Chinese Medicine,Shenzhen 518000,China;Post-Doctoral Research Center,Longgang Central Hospital,Shenzhen 518116,China;Department of Imaging,Xiamen Ping'an Haoyi Medical Imaging Diagnostic Center,Xiamen 361015,China;Circle Cardiovascular Imaging,Calgary T2P 3T6,Canada;Department of Radiology,Xiamen Zhouxin Medical Imaging Diagnostic Center,Xiamen 361000,China;Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]广州中医药大学深圳临床医学院,广东深圳518000 [2]深圳市龙岗中心医院博士后科研工作站,广东深圳518116 [3]厦门平安好医医学影像诊断中心影像科,福建厦门361015 [4]加拿大圆心血管影像有限公司,加拿大卡尔加里T2P 3T6 [5]厦门州信医学影像诊断中心放射科,福建厦门361000 [6]首都医科大学宣武医院放射与核医学科,北京100053

出　　处：《中国医学影像技术》2022年第1期12-16,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察健康成人左心室重构与血脂比值的独立相关性。方法收集352名接受心脏MR(CMR)检查的健康体检者资料,测量其心脏周围脂肪组织(PAT)体积、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、每搏输出量(SV)、射血分数(EF)和舒张末期左心室心肌质量(LVM)等,计算左心室重构指数(LVRI),即LVM/LVEDV;同时检测其血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C),计算血脂比值TC/HDL-C、TG/HDL-C及LDL-C/HDL-C;观察LVRI与血脂比值的相关性。结果LVRI与TC/HDL-C、TG/HDL-C及LDL-C/HDL-C均呈低度正相关(r=0.414、0.441、0.407,P均<0.05)。分别以TC/HDL-C、TG/HDL-C及LDL-C/HDL-C为自变量,以LVRI为因变量,以校正后的年龄、性别、心率、空腹血糖、收缩压及体表面积各因素建立多元线性回归模型1,结果显示LVRI与TC/HDL-C、TG/HDL-C及LDL-C/HDL-C均呈正相关(β=0.175、0.161、0.181,P均<0.05);在此基础上加入校正后PAT体积建立模型2,结果显示LVRI与TC/HDL-C、TG/HDL-C及LDL-C/HDL-C均呈正相关(β=0.149、0.137、0.167,P均<0.05)。结论健康成人左心室重构与血脂比值呈独立正相关,提示临床需早期防控血脂异常。Objective To analyze the independent correlation of left ventricular remodeling and lipid ratios in healthy adults.Methods Totally 352 healthy adults who underwent cardiac MR(CMR)examination were enrolled.The pericardial adipose tissue(PAT)volume,left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),stroke volume(SV),ejection fraction(EF)and left ventricular mass(LVM)were measured,and the left ventricular remodeling index(LVRI),i.e.LVM/LVEDV were calculated.Meanwhile,the serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were tested,and the lipid ratios TC/HDL-C,TG/HDL-C and LDL-C/HDL-C were calculated.The correlations between LVRI and lipid ratios were observed.Results LVRI was lowly positively correlated with TC/HDL-C,TG/HDL-C and LDL-C/HDL-C(r=0.414,0.441,0.407,all P<0.05).Taken TC/HDL-C,TG/HDL-C and LDL-C/HDL-C as independent variables and LVRI as dependent variables,multiple linear regression model 1 was established with the corrected impact factors including age,sex,heart rate,fasting blood glucose,systolic blood pressure and body surface area,and the results showed that LVRI was positively correlated with TC/HDL-C,TG/HDL-C and LDL-C/HDL-C(β=0.175,0.161,0.181,all P<0.05).Based on the above factors,model 2 was established with additionally corrected PAT volume,and the results showed that LVRI was positively correlated with TC/HDL-C,TG/HDL-C and LDL-C/HDL-C(β=0.149,0.137,0.167,all P<0.05).Conclusion There were positive independent correlations between left ventricular remodeling and lipid ratios in healthy adults,suggesting the importance of early prevention and control of dyslipidemia.

关 键 词：心室重塑 心脏 血脂 磁共振成像 

分 类 号：R331[医药卫生—人体生理学] R445.2[医药卫生—基础医学]