高分子医用组织胶粘剂的应用与研究进展  

The Applications and Research Progress of Polymeric Medical Tissue Adhesives

作　　者：孙文 闫秋艳[1] 苏超 栾世方 殷敬华[1] SUN Wen;YAN Qiuyan;SU Chao;LUAN Shifang;YIN Jinghua(Changchun Institute of Applied Chemistry Chinese Academy of Sciences,Changchun 130022,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China;Weihai Science and Technology Innovation Development Center,Weihai 264200,Shandong,China)

机构地区：[1]中国科学院长春应用化学研究所,长春130022 [2]中国科学技术大学应用化学与工程学院,合肥230026 [3]威海市科技创新发展中心,山东威海264200

出　　处：《材料导报》2022年第3期1-17,共17页Materials Reports

基　　金：国家重点研发计划(2021YFC2101700);中国科学院-威高集团高新技术研发计划。

摘　　要：高分子医用组织胶粘剂由于具有优异的性能,受到医疗领域的广泛关注,适用于轻微至危及生命的各种组织损伤的闭合与再生。与传统的伤口缝合方法(缝合线和缝合钉)相比,胶粘剂使用方便、闭合伤口速度快、对组织的损伤小。目前,高分子医用胶粘剂以多种形式用于伤口处理,如止血剂、粘合剂和密封剂。尽管组织胶粘剂目前应用广泛,但仍面临一些限制和未解决的挑战(例如较弱的湿态粘附强度和缺乏生物功能等),这限制了它们的使用,为未来的改进留下了充足的空间。基于组织胶粘剂界面的化学和物理特性、组织粘连的基本机制以及特定临床应用的要求,本文总结了组织胶粘剂的基本设计原则及湿态粘附机制,基于组织特异性的考虑,介绍了该领域的最新研究进展,并展望了未来组织胶粘剂的潜在功能和临床需求。The polymer medical tissue adhesive has received extensive attention in the medical field due to its excellent performance,and are widely used in a variety of medical settings ranging from minor to life-threatening tissue injuries.Compared to the traditional methods of wound closure(i.e.,suturing and stapling),they are relatively easy to use,enable rapid application,and introduce minimal tissue damage.Polymeric tissue adhesives can provide versatile materials for wound management,and can be used as hemostatic agents,adhesives and sealants.Despite their numerous current applications,tissue adhesives still face several limitations and unresolved challenges(e.g.,weak wet adhesion strength and poor biological function).Successful development of next-generation adhesives will likely require a holistic understanding of the chemical and physical properties of the tissue-adhesive interface,fundamental mechanisms of tissue adhesion,and requirements for specific clinical applications.In this review,we discussed the basic design principles and wet adhesion mechanism of tissue adhesives.Based on the consideration of tissue specificity,we introduced the latest research progress in this field and looked forward to the potential functions and clinical needs of tissue adhesives in the future,hoping to provide a valuable reference for the progress in the field of tissue adhesive.

关 键 词：组织胶粘剂 粘附机制 湿态粘附 组织修复 

分 类 号：TB324[一般工业技术—材料科学与工程]