肠道菌群在多囊卵巢综合征中的作用及中医治疗研究进展  

Role of intestinal flora in polycystic ovary syndrome and the research progress of TCM treatment

作　　者：夏璐 张真真[1,2] 万贵平[1,2] XIA Lu;ZHANG Zhenzhen;WAN Guiping(Department of Obstetrics and Gynecology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Nanjing University of Chinese Medicine,Jiangsu,Nanjing 210028,China;Jiangsu Province Academy of Traditional Chinese Medicine,Jiangsu,Nanjing 210028,China)

机构地区：[1]南京中医药大学附属中西医结合医院妇产科,江苏南京210028 [2]江苏省中医药研究院,江苏南京210028

出　　处：《中国医药科学》2021年第24期77-80,共4页China Medicine And Pharmacy

摘　　要：多囊卵巢综合征(PCOS)好发于育龄期妇女,以月经失调、不孕等为主要临床表现,发病率逐年升高。目前西医治疗以降低雄激素、改善胰岛素抵抗、促排卵为主,但有一定的局限性,包括疗效欠佳、并发症多等。多项研究发现,PCOS发生发展与肠道菌群相关。肠道菌群被称为“人类第二大基因组”“被遗忘的器官”,近年来成为感染性、免疫性以及代谢性疾病的研究热点。本文主要从肠道菌群失调所致的高雄激素血症、胰岛素抵抗、慢性炎症及代谢综合征探讨与PCOS发生和发展的相关性。中医运用中药复方、针灸等方式调和胃肠肝脾、平衡肠道菌群、维持肠道内环境稳态,为PCOS病因病机的认识及治疗提供新的切入点。Polycystic ovary syndrome(PCOS)occurs frequently in women of childbearing age,with menstrual disorder and infertility as the main clinical manifestations,and the incidence is increasing year by year.At present,western medicine mainly reduces androgen,improves insulin resistance and promotes ovulation,but it has some limitations,including poor curative effect and many complications.Many studies have found that the occurrence and development of PCOS is related to intestinal flora.Intestinal flora is called"the second largest human genome"and"forgotten organ",and it has become the research focus of infectious,immune and metabolic diseases in recent years.This article mainly discusses the correlation between hyperandrogenism,insulin resistance,chronic inflammation and metabolic syndrome caused by intestinal flora imbalance and the occurrence and development of PCOS.The use of traditional Chinese medicine(TCM)compound prescription,acupuncture and other methods to regulate the stomach,intestine,liver and spleen,balance the intestinal flora,maintain the homeostasis of the intestinal environment,and provide a new breakthrough point for the understanding and treatment of the etiology and pathogenesis of PCOS.

关 键 词：多囊卵巢综合征 肠道菌群 相关性 中医治疗 

分 类 号：R614.2[医药卫生—麻醉学] R-1[医药卫生—外科学]