3-碘甲状腺原氨酸的受体、通路及药理学效应研究进展  

Research progress of receptor,pathway and pharmacological effect of 3-iodothyronamine

作　　者：莫丽莉 邹常超 徐启丽 韦波 李伟 曾安宁 陈章荣 刘兴德 周海燕 MO Lili;ZOU Changchao;XU Qili;WEI Bo;LI Wei;ZENG Anning;CHEN Zhangrong;LIU Xingde;ZHOU Haiyan(Dept.of Cardiology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China;School of Clinical Medicine,Guizhou Medical University,Guiyang 550004,China;Dept.of Cardiology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550004,China;Dept.of Cardiology,Qiannan Buyi and Miao Autonomous Prefecture People’s Hospital,Guizhou Duyun 558000,China)

机构地区：[1]贵州医科大学附属医院心血管内科,贵阳550004 [2]贵州医科大学临床医学院,贵阳550004 [3]贵州中医药大学第二附属医院心血管内科,贵阳550004 [4]黔南布依族苗族自治州人民医院心血管内科,贵州都匀558000

出　　处：《中国药房》2022年第2期244-250,共7页China Pharmacy

基　　金：国家自然科学基金资助项目(No.31760294);贵州省科技计划项目(No.黔科合平台人才〔2018〕5779-38);贵阳市科技计划项目(No.筑科合同〔2021〕43-6)。

摘　　要：3-碘甲状腺原氨酸是甲状腺激素的内源性衍生物,也可作为外源性药物使用,可发挥减少心输出量、冠脉流量,减慢心率,促进脂肪分解,降低基础代谢,改善学习及记忆能力等药理学效应。其对代谢的调节作用与甲状腺素类似,而对心脏的调节作用及产热功能则与其相反。3-碘甲状腺原氨酸作为一种新型化学信使,可通过多种受体及信号通路发挥不同的药理学效应。本文就外源性3-碘甲状腺原氨酸发挥的多种药理学效应及其机制的研究进展作一综述,以期为心血管、代谢性疾病及神经系统疾病提供新的治疗药物。3-iodothyronamine(T1AM)is an endogenous derivative of thyroid hormone.It can also be used as exogenous drug.It can play pharmacological effects such as reducing cardiac output and coronary flow,slowing heart rate,promoting lipolysis,reducing basic metabolism and improving learning and memory ability.Its regulatory effect on metabolism is similar to that of thyroxine,but regulatory effect on heart and thermogenic function is opposite to that of thyroxine.As a new chemical messenger,T1AM can exert different pharmacological effects through a variety of receptors and signal pathways.This review summarizes the research progress of various pharmacological effects and mechanisms of exogenous T1AM,in order to provide new therapeutic drugs of cardiovascular,metabolic diseases and nervous system diseases.

关 键 词：3-碘甲状腺原氨酸 受体 信号通路 药理学效应 

分 类 号：R96[医药卫生—药理学]