Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues  

作　　者：Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao 

机构地区：[1]Department of Orthopedics,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen,Guangdong,China [2]Department of Biochemistry,School of Medicine,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,Southern University of Science and Technology,Shenzhen,Guangdong,China [3]Department of Orthopedics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China

出　　处：《Bone Research》2021年第4期456-472,共17页骨研究（英文版）

基　　金：This work was supported by the National Key Research and Development Program of China Grant(2019YFA0906004);the National Natural Science Foundation of China Grants(81991513,82022047,81630066,81870532,81972100);the Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018);the Science and Technology Innovation Commission of Shenzhen Municipal Government Grants(JCYJ20180302174117738,JCYJ20180302174246105,KQJSCX20180319114434843,JSGG20180503182321166);the China Postdoctoral Science Foundation(2019M651641).

摘　　要：Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal environments.The mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in cells.The Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus far.The regulation of two family members,Piezol and Piezo2#has been reported to have essential functions in mechanosensation and transduction in different organs and tissues.Recently,the predominant contributions of the Piezo family were reported to occur in the skeletal system,especially in bone development and mechano-stimulated bone homeostasis.Here we review current studies focused on the tissue-specific functions of Piezol and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell mechanotransduction.In this review,we emphasize the diverse functions of Piezol and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes.We also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases.

关 键 词：MEC SENSATION ORGANS 

分 类 号：TQ936[化学工程] R318.08[医药卫生—生物医学工程]