慢性血栓栓塞性肺动脉高压新治疗方法的进展  

Chronic Thromboembolic Pulmonary Hypertension:Evolving Therapeutic Approaches

作　　者：王高峰 管丽华 周达新 WANG Gaofeng;GUAN Lihua;ZHOU Daxin(Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院心血管内科,上海200032

出　　处：《心血管病学进展》2022年第1期14-17,共4页Advances in Cardiovascular Diseases

基　　金：上海市科委基金(14ZR1406700)。

摘　　要：慢性血栓栓塞性肺动脉高压是由于肺动脉血栓未完全溶解导致的一类毛细血管前性肺动脉高压。肺动脉内膜剥脱术是目前慢性血栓栓塞性肺动脉高压的首选治疗方案。但很多患者因远端血管病变或严重合并症而无法手术,或手术后有持续性肺动脉高压,球囊肺血管成形术和靶向药物的发展为这些患者的治疗带来了新的希望。现就慢性血栓栓塞性肺动脉高压新疗法的进展做一综述。Chronic thromboembolic pulmonary hypertension is a type of precapillary pulmonary hypertension resulting from incomplete resolution of pulmonary embolism.At present,pulmonary endarterectomy is the preferred therapy.However,many patients are inoperable due to either distal pulmonary vascular obstruction or significant comorbidities,and some patients have persistent pulmonary hypertension after undergoing pulmonary endarterectomy.The development of balloon pulmonary angioplasty and targeted drugs have brought new hope to these patients.The paper reviews the evolving therapeutic approaches for chronic thromboembolic pulmonary hypertension.

关 键 词：慢性血栓栓塞性肺动脉高压 肺动脉内膜剥脱术 球囊肺血管成形术 靶向药物 

分 类 号：R54[医药卫生—心血管疾病]