白介素-1家族在急性冠状动脉综合征发生和发展过程中的机制及治疗现状进展  

Mechanism and Treatment Status of Interleukin-1 Family in Occurrence and Development of Acute Coronary Syndrome

作　　者：白斯特 潘建华 蔡梦珊 姜馨[3] BAI Site;PAN Jianhua;CAI Mengshan;JIANG Xin(Xi’an Medical University,Xi’an 710068,Shaanxi,China;Department of Radiology,Shaanxi Kangfu Hospital,Xi’an 710065,Shaanxi,China;Department of Cardiovascular Medicine,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi,China)

机构地区：[1]西安医学院,陕西西安710068 [2]陕西省康复医院影像科,陕西西安710065 [3]陕西省人民医院心血管内科,陕西西安710068

出　　处：《心血管病学进展》2022年第1期64-67,共4页Advances in Cardiovascular Diseases

基　　金：陕西省重点研发计划项目(2019ZDLSF01-01-01)。

摘　　要：白介素(IL)-1家族是一类发现较早且作用广泛的炎症细胞因子,在急性冠状动脉综合征的发生和发展过程中发挥着至关重要的作用。IL-1家族成员包括IL-1α、IL-1β、IL-1Ra、IL-18、IL-33、IL-36α、IL-36β、IL-36γ、IL-36Ra、IL-37和IL-38。它们在急性冠状动脉综合征的发生和发展过程中展现出各自的抗炎及促炎作用。目前已有研究探索将其用于急性冠状动脉综合征的治疗并取得良好效果。现对IL-1家族参与急性冠状动脉综合征发生和发展的机制及治疗现状进行综述。Interleukin(IL)-1 family is a kind of inflammatory cytokines found earlier and widely used.It plays an important role in the occurrence and development of acute coronary syndrome.Members of the IL-1 family include IL-1α,IL-1β,IL-1Ra,IL-18,IL-33,IL-36α,IL-36β,IL-36γ,IL-36Ra,IL-37 and IL-38.They respectively exhibit anti-inflammatory and pro-inflammatory effects in the development of acute coronary syndrome.At present,studies have explored its use in the treatment of acute coronary syndrome and achieved good results.This paper reviews the mechanism and treatment status of IL-1 family involved in the occurrence and development of acute coronary syndrome.

关 键 词：白介素-1 急性冠状动脉综合征 细胞因子 炎症 

分 类 号：R54[医药卫生—心血管疾病]